Application of the Rosner-Colditz Risk Prediction Model to Estimate Sexual Orientation Group Disparities in Breast Cancer Risk in a U.S. Cohort of Premenopausal Women
Published Date:Oct 03 2012
Source:Cancer Epidemiol Biomarkers Prev. 21(12):2201-2208.
Pubmed Central ID:PMC3518622
Funding:AG/CA14742/AG/NIA NIH HHS/United States
CA50385/CA/NCI NIH HHS/United States
CA65725/CA/NCI NIH HHS/United States
CA67262/CA/NCI NIH HHS/United States
CA67883/CA/NCI NIH HHS/United States
DK52866/DK/NIDDK NIH HHS/United States
DK59583/DK/NIDDK NIH HHS/United States
HD40882/HD/NICHD NIH HHS/United States
HL03804/HL/NHLBI NIH HHS/United States
HL64108/HL/NHLBI NIH HHS/United States
R01 CA050385/CA/NCI NIH HHS/United States
T71-MC00009/PHS HHS/United States
U48DP00192/DP/NCCDPHP CDC HHS/United States
Lesbian and bisexual women may be at greater risk of breast cancer than heterosexual women during the premenopausal period due to disparities in risk factors.
With 16 years of prospective data from a large cohort of U.S. women ages 25–58 years, we conducted a breast cancer risk assessment for 87,392 premenopausal women by applying the Rosner-Colditz biomathematical risk-prediction model to estimate breast cancer risk based on known risk factors. Based on each woman’s comprehensive risk factor profile, we calculated the predicted one-year incidence rate (IR) per 100,000 person-years and estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) for lesbian and bisexual women compared to heterosexual women.
87,392 premenopausal women provided 1,091,871 person-years of data included in analyses. Mean predicted one-year breast cancer IRs per 100,000 person-years for each sexual orientation group were: heterosexual 122.55, lesbian 131.61, and bisexual 131.72. IRs were significantly elevated in both lesbian (IRR 1.06; 95 CI 1.06, 1.06) and bisexual (IRR 1.10; 95% CI 1.10, 1.10) women compared to heterosexual women.
Our findings suggest both lesbian and bisexual women have slightly elevated predicted breast cancer incidence compared to heterosexual women throughout the premenopausal period.
Health professionals must ensure that breast cancer prevention efforts are reaching these women. As more health systems around the country collect data on patient sexual orientation, the National Cancer Institute’s SEER cancer registry should add this information to its data system to monitor progress in reducing sexual orientation-related disparities in cancer incidence and mortality.
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