Application of the Rosner-Colditz Risk Prediction Model to Estimate Sexual Orientation Group Disparities in Breast Cancer Risk in a U.S. Cohort of Premenopausal Women

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Austin, S. Bryn ; Pazaris, Mathew J. ; Rosner, Bernard ; Bowen, Deborah ; Rich-Edwards, Janet ; Spiegelman, Donna
• Description:
  Background
  
  Lesbian and bisexual women may be at greater risk of breast cancer than heterosexual women during the premenopausal period due to disparities in risk factors.
  
  Methods
  
  With 16 years of prospective data from a large cohort of U.S. women ages 25–58 years, we conducted a breast cancer risk assessment for 87,392 premenopausal women by applying the Rosner-Colditz biomathematical risk-prediction model to estimate breast cancer risk based on known risk factors. Based on each woman’s comprehensive risk factor profile, we calculated the predicted one-year incidence rate (IR) per 100,000 person-years and estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) for lesbian and bisexual women compared to heterosexual women.
  
  Results
  
  87,392 premenopausal women provided 1,091,871 person-years of data included in analyses. Mean predicted one-year breast cancer IRs per 100,000 person-years for each sexual orientation group were: heterosexual 122.55, lesbian 131.61, and bisexual 131.72. IRs were significantly elevated in both lesbian (IRR 1.06; 95 CI 1.06, 1.06) and bisexual (IRR 1.10; 95% CI 1.10, 1.10) women compared to heterosexual women.
  
  Conclusions
  
  Our findings suggest both lesbian and bisexual women have slightly elevated predicted breast cancer incidence compared to heterosexual women throughout the premenopausal period.
  
  Impact
  
  Health professionals must ensure that breast cancer prevention efforts are reaching these women. As more health systems around the country collect data on patient sexual orientation, the National Cancer Institute’s SEER cancer registry should add this information to its data system to monitor progress in reducing sexual orientation-related disparities in cancer incidence and mortality.
  
  
• Subjects:
  Adult Aged Bisexuality Breast Neoplasms Cohort Studies Female Homosexuality, Female Humans Incidence Longitudinal Studies Middle Aged Models, Statistical Premenopause Prospective Studies Questionnaires Risk

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 21(12):2201-2208.
• Pubmed ID:
  23035180
• Pubmed Central ID:
  PMC3518622
• Document Type:
  Journal Article
• Funding:
  AG/CA14742/AG/NIA NIH HHS/United States ; CA50385/CA/NCI NIH HHS/United States ; CA65725/CA/NCI NIH HHS/United States ; CA67262/CA/NCI NIH HHS/United States ; CA67883/CA/NCI NIH HHS/United States ; DK52866/DK/NIDDK NIH HHS/United States ; DK59583/DK/NIDDK NIH HHS/United States ; HD40882/HD/NICHD NIH HHS/United States ; HL03804/HL/NHLBI NIH HHS/United States ; HL64108/HL/NHLBI NIH HHS/United States ; R01 CA050385/CA/NCI NIH HHS/United States ; T71-MC00009/PHS HHS/United States ; U48DP00192/DP/NCCDPHP CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  21
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c80129072a05d467b4ef0104100664439c144faf32f997b3db931a6de4cc6011
• Download URL:
  https://stacks.cdc.gov/view/cdc/33490/cdc_33490_DS1.pdf
• File Type:
  [PDF - 383.59 KB ]