Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with Familial Hyperparathyroidism-Jaw Tumor Syndrome

Details

• Alternative Title:
  Fertil Steril
• Personal Author:
  Wolff, Erin F. ; Hill, Micah J. ; Simonds, William F. ; Segars, James H.
• Description:
  Objective
  
  To describe the clinical management of menorrhagia in a woman with Hyperparathyroidism-Jaw Tumor Syndrome (HPT-JT).
  
  Design
  
  Case report.
  
  Setting
  
  Large translation research hospital.
  
  Patient
  
  A 26 year old nulligravid woman with familial HPT-JT presented with life-long menorrhagia resistant to progesterone IUD therapy and a desire for fertility.
  
  Intervention
  
  Aromatase inhibitor therapy.
  
  Main Outcome Measures
  
  Clinical response to therapy and pregnancy.
  
  Result
  
  Imaging demonstrated an enlarged endometrial lining and thickening of the junctional zone. At operative hysteroscopy, multiple atypical endometrial polyp-like lesions filled the entire uterine cavity and were removed. Histologic evaluation demonstrated the lesions to be adenomyomas with an abundance of aromatase expression. Postoperative treatment included an aromatase inhibitor. The patient's menorrhagia, which had previously been resistant to progesterone IUD therapy, resolved with the aromatase inhibitor. After ten months of this treatment, the aromatase inhibitor was discontinued and a repeat hysteroscopy revealed a markedly improved uterine cavity. The patient subsequently became pregnant on her first natural cycle and delivered a healthy term infant.
  
  Conclusion
  
  Aromatase inhibitors may represent a novel treatment for benign uterine pathology in HPT-JT.
  
  
• Subjects:
  Adenoma Adenomyoma Aromatase Inhibitor Aromatase Inhibitors Article Female Fibroma Humans Hyperparathyroidism Hyperparathyroidism-jaw Tumor Syndrome Infertility, Female Jaw Neoplasms Live Birth Menorrhagia Ovulation Induction Pregnancy Treatment Outcome

  More +
• Source:
  Fertil Steril. 98(6):1616-1619
• Pubmed ID:
  22963808
• Pubmed Central ID:
  PMC3513668
• Document Type:
  Journal Article
• Funding:
  Z99 HD999999/Intramural NIH HHS/United States ; ZIA HD008924-01/Intramural NIH HHS/United States ; Z01 HD008924-01/HD/NICHD NIH HHS/United States ; Z01 ND008737-12/ND/ONDIEH CDC HHS/United States
• Volume:
  98
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:99c674b79defe39c61123d0be546bfdeb2ac4fad7027941bf2bf98d8cc7c1bfc
• Download URL:
  https://stacks.cdc.gov/view/cdc/33484/cdc_33484_DS1.pdf
• File Type:
  [PDF - 2.82 MB ]