Details:

Alternative Title:
Fertil Steril
Personal Author:
Wolff, Erin F. ; Hill, Micah J. ; Simonds, William F. ; Segars, James H. ;
Wolff, Erin F. ; Hill, Micah J. ; Simonds, William F. ; Segars, James H. ; Less -
Description:
Objective To describe the clinical management of menorrhagia in a woman with Hyperparathyroidism-Jaw Tumor Syndrome (HPT-JT). Design Case report. Setting Large translation research hospital. Patient A 26 year old nulligravid woman with familial HPT-JT presented with life-long menorrhagia resistant to progesterone IUD therapy and a desire for fertility. Intervention Aromatase inhibitor therapy. Main Outcome Measures Clinical response to therapy and pregnancy. Result Imaging demonstrated an enlarged endometrial lining and thickening of the junctional zone. At operative hysteroscopy, multiple atypical endometrial polyp-like lesions filled the entire uterine cavity and were removed. Histologic evaluation demonstrated the lesions to be adenomyomas with an abundance of aromatase expression. Postoperative treatment included an aromatase inhibitor. The patient's menorrhagia, which had previously been resistant to progesterone IUD therapy, resolved with the aromatase inhibitor. After ten months of this treatment, the aromatase inhibitor was discontinued and a repeat hysteroscopy revealed a markedly improved uterine cavity. The patient subsequently became pregnant on her first natural cycle and delivered a healthy term infant. Conclusion Aromatase inhibitors may represent a novel treatment for benign uterine pathology in HPT-JT.
Subject:
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Adenoma
Adenomyoma
Aromatase Inhibitor
Aromatase Inhibitors
Article
Female
Fibroma
Humans
Hyperparathyroidism
Hyperparathyroidism-jaw Tumor Syndrome
Infertility, Female
Jaw Neoplasms
Live Birth
Menorrhagia
Ovulation Induction
Pregnancy
Treatment Outcome

Source:
Fertil Steril. 98(6):1616-1619
Pubmed ID:
22963808
Pubmed Central ID:
PMC3513668
Document Type:
Journal Article ;
Funding:
Z99 HD999999/Intramural NIH HHS/United States ; ZIA HD008924-01/Intramural NIH HHS/United States ; Z01 HD008924-01/HD/NICHD NIH HHS/United States ; Z01 ND008737-12/ND/ONDIEH CDC HHS/United States ;
Z99 HD999999/Intramural NIH HHS/United States ; ZIA HD008924-01/Intramural NIH HHS/United States ; Z01 HD008924-01/HD/NICHD NIH HHS/United States ; Z01 ND008737-12/ND/ONDIEH CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:99c674b79defe39c61123d0be546bfdeb2ac4fad7027941bf2bf98d8cc7c1bfc
File Type:

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