Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with Familial Hyperparathyroidism-Jaw Tumor Syndrome
Published Date:Sep 08 2012
Source:Fertil Steril. 98(6):1616-1619.
Pubmed Central ID:PMC3513668
Funding:Z01 HD008924-01/HD/NICHD NIH HHS/United States
Z01 ND008737-12/ND/ONDIEH CDC HHS/United States
Z99 HD999999/Intramural NIH HHS/United States
ZIA HD008924-01/Intramural NIH HHS/United States
To describe the clinical management of menorrhagia in a woman with Hyperparathyroidism-Jaw Tumor Syndrome (HPT-JT).
Large translation research hospital.
A 26 year old nulligravid woman with familial HPT-JT presented with life-long menorrhagia resistant to progesterone IUD therapy and a desire for fertility.
Aromatase inhibitor therapy.
Main Outcome Measures
Clinical response to therapy and pregnancy.
Imaging demonstrated an enlarged endometrial lining and thickening of the junctional zone. At operative hysteroscopy, multiple atypical endometrial polyp-like lesions filled the entire uterine cavity and were removed. Histologic evaluation demonstrated the lesions to be adenomyomas with an abundance of aromatase expression. Postoperative treatment included an aromatase inhibitor. The patient's menorrhagia, which had previously been resistant to progesterone IUD therapy, resolved with the aromatase inhibitor. After ten months of this treatment, the aromatase inhibitor was discontinued and a repeat hysteroscopy revealed a markedly improved uterine cavity. The patient subsequently became pregnant on her first natural cycle and delivered a healthy term infant.
Aromatase inhibitors may represent a novel treatment for benign uterine pathology in HPT-JT.
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