Details:

Alternative Title:
Am J Obstet Gynecol
Personal Author:
Margulis, Andrea V ; Mitchell, Allen A ; Gilboa, Suzanne M ; Werler, Martha M ; Mittleman, Murray A ; ... More +
Margulis, Andrea V ; Mitchell, Allen A ; Gilboa, Suzanne M ; Werler, Martha M ; Mittleman, Murray A ; Glynn, Robert J ; Hernandez-Diaz, Sonia ; Less -
Corporate Authors:
National Birth Defects Prevention Study ;
Description:
Objective To evaluate the association between monotherapy topiramate use in pregnancy and cleft lip with or without cleft palate (CL/P) in the offspring. Study design Data from the Slone Epidemiology Center Birth Defects Study (BDS) from 1997–2009 and the National Birth Defects Prevention Study (NBDPS) from 1997–2007 were analyzed. Conditional logistic regression was used to compare first-trimester use of topiramate monotherapy to no antiepileptic drug use during the periconceptional period between mothers of infants with CL/P and mothers of controls for each study separately, and in pooled data. Results BDS contained 785 CL/P cases and 6,986 controls; NBDPS contained 2,283 CL/P cases and 8,494 controls. The odds ratios (exact 95% confidence intervals) for the association between topiramate use and CL/P were 10.1 (1.1; 129.2) in BDS, 3.6 (0.7; 20.0) in NBDPS, and 5.4 (1.5; 20.1) in pooled data. Conclusions First-trimester use of topiramate may be associated with CL/P.
Subject:
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Adult
Anticonvulsants
Antiepileptic Drugs
Article
Birth Defects
Case-Control Studies
Cleft Lip
Cleft Palate
Epilepsy
Female
Fructose
Humans
Incidence
Oral Clefts
Pregnancy
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects
Prevalence
Risk
Topiramate
Young Adult
Cleft Lip

Source:
Am J Obstet Gynecol. 2012; 207(5):405.e1-405.e7
Pubmed ID:
22917484
Pubmed Central ID:
PMC3484193
Document Type:
Journal Article ;
Funding:
FOA DD09-001/DD/NCBDD CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 HD046595/HD/NICHD NIH HHS/United States ; PA 02081/PHS HHS/United States ; PA 96043/PHS HHS/United States ; ... More +
FOA DD09-001/DD/NCBDD CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 HD046595/HD/NICHD NIH HHS/United States ; PA 02081/PHS HHS/United States ; PA 96043/PHS HHS/United States ; R01 HD 046595/HD/NICHD NIH HHS/United States ; U50/CCU113247/PHS HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ba62bbc5999016e0c684a8ae853b2d8c406349ac76da8268609b95288aeb7a73
File Type:

Supporting Files

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