Content
and Copyright
i
Use of topiramate in pregnancy and risk of oral clefts
-
Published Date:
July 16 2012
Source:Am J Obstet Gynecol. 2012; 207(5):405.e1-405.e7Language:English
[PDF-51.66 KB]
Details:
-
Alternative Title:Am J Obstet Gynecol
-
Personal Author:
-
Corporate Authors:
-
Description:Objective To evaluate the association between monotherapy topiramate use in pregnancy and cleft lip with or without cleft palate (CL/P) in the offspring. Study design Data from the Slone Epidemiology Center Birth Defects Study (BDS) from 1997–2009 and the National Birth Defects Prevention Study (NBDPS) from 1997–2007 were analyzed. Conditional logistic regression was used to compare first-trimester use of topiramate monotherapy to no antiepileptic drug use during the periconceptional period between mothers of infants with CL/P and mothers of controls for each study separately, and in pooled data. Results BDS contained 785 CL/P cases and 6,986 controls; NBDPS contained 2,283 CL/P cases and 8,494 controls. The odds ratios (exact 95% confidence intervals) for the association between topiramate use and CL/P were 10.1 (1.1; 129.2) in BDS, 3.6 (0.7; 20.0) in NBDPS, and 5.4 (1.5; 20.1) in pooled data. Conclusions First-trimester use of topiramate may be associated with CL/P.
-
Subject:
-
Pubmed ID:22917484
-
Pubmed Central ID:PMC3484193
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
text/xml
No Related Documents.
You May Also Like:
-
Published Date:Source:Description:File Type:[PDF - 101.30 KB]
File Type:[PDF - 101.30 KB]
Published Date:Source:Description:File Type:[PDF - 127.89 KB]
File Type:[PDF - 127.89 KB]
Published Date:Source:Description:File Type:[PDF - 517.84 KB]
File Type:[PDF - 517.84 KB]
Published Date:Source:Description:File Type:[PDF - 311.19 KB]
File Type:[PDF - 311.19 KB]
Published Date:Source:Description:File Type:[PDF - 527.33 KB]
File Type:[PDF - 527.33 KB]
Have Questions?
Visit CDC Info
Email
CDC-INFO
Open 24/7
CDC INFORMATION
CONNECT WITH CDC
