Asymmetry and aging of mycobacterial cells leads to variable growth and antibiotic susceptibility

Aldridge, Bree B.; Fernandez-Suarez, Marta; Heller, Danielle; Ambravaneswaran, Vijay; Irimia, Daniel; Toner, Mehmet; Fortune, Sarah

doi:10.1126/science.1216166

Back to Previous Page

Asymmetry and aging of mycobacterial cells leads to variable growth and antibiotic susceptibility

Published Date:

Dec 15 2011

Publisher's site:

http://dx.doi.org/10.1126/science.1216166

Source:

Science. 335(6064):100-104.

[PDF-1.98 MB]

Details:

Alternative Title:

Science

Personal Author:

Aldridge, Bree B. ; Fernandez-Suarez, Marta ; Heller, Danielle ; Ambravaneswaran, Vijay ; Irimia, Daniel ; ... More ▼

Description:

Cells use both deterministic and stochastic mechanisms to generate cell-to-cell heterogeneity, which enables the population to better withstand environmental stress. Here we show that, within a clonal population of mycobacteria, there is deterministic heterogeneity in elongation rate that arises because mycobacteria grow in an unusual, unipolar fashion. Division of the asymmetrically growing mother cell gives rise to daughter cells that differ in elongation rate and size. Because the mycobacterial cell division cycle is governed by time, not cell size, rapidly elongating cells do not divide more frequently than slowly elongating cells. The physiologically distinct subpopulations of cells that arise through asymmetric growth and division are differentially susceptible to clinically important classes of antibiotics.

Subject:

[+]

Pubmed ID:

22174129

Pubmed Central ID:

PMC3397429

Document Type:

Journal Article

Funding:

1DP20D001378/DP/NCCDPHP CDC HHS/United States ; DP2 OD001378/OD/NIH HHS/United States ; P30 AI060354/AI/NIAID NIH HHS/United States ; P41 EB002503/EB/NIBIB NIH HHS/United States ; P41 EB002503/EB/NIBIB NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

	nihms389397f4.gif	image/gif
	nihms389397f4.jpg	image/jpeg
	NIHMS389397-supplement-Supplementary_Data.pdf	application/pdf
	nihms389397.nxml	text/plain
	nihms389397f1.gif	image/gif
	nihms389397f1.jpg	image/jpeg
	nihms389397f2.gif	image/gif
	nihms389397f2.jpg	image/jpeg
	nihms389397f3.gif	image/gif
	nihms389397f3.jpg	image/jpeg

No Related Documents.

RIFAMPIN-RESISTANT TUBERCULOSIS IN THE UNITED STATES, 1998–2014

[PDF - 393.81 KB]

Personal Author:

Sharling, Lisa ; Marks, Suzanne M. ; ...

Published Date:

April 10 2020

Source:

Clin Infect Dis. 70(8):1596-1605

Description:

BackgroundMonoresistance to rifamycins necessitates longer and more toxic regimens for tuberculosis (TB). We examined characteristics and mortality as...

File Type:

[PDF - 393.81 KB]

File Type:

[PDF - 393.81 KB]
Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals

[PDF - 471.49 KB]

Personal Author:

Hostler, Christopher J. ; Moehring, Rebekah W. ; ...

Published Date:

April 23 2018

Source:

Infect Control Hosp Epidemiol. 39(6):718-722

Description:

OBJECTIVE.To determine the feasibility and value of developing a regional antibiogram for community hospitals.DESIGN.Multicenter retrospective analysi...

File Type:

[PDF - 471.49 KB]

File Type:

[PDF - 471.49 KB]
Dana Cole, Georgia Division of Public Health, Notifiable Disease Section, Department of Human Resources, 2 Peachtree Free-living Canada Geese and Antimicrobial Resistance

[PDF - 232.64 KB]

Personal Author:

Cole, Dana ; Drum, David J.V. ; ...

Published Date:

Jun 2005

Source:

Emerg Infect Dis. 11(6):935-938.

Description:

We describe antimicrobial resistance among Escherichia coli isolated from free-living Canada Geese in Georgia and North Carolina (USA). Resistance pat...

File Type:

[PDF - 232.64 KB]

File Type:

[PDF - 232.64 KB]
Carbapenem Resistance in Klebsiella pneumoniae Not Detected by Automated Susceptibility Testing

[PDF - 105.46 KB]

Personal Author:

Tenover, Fred C. ; Kalsi, Rajinder K. ; ...

Published Date:

Aug 2006

Source:

Emerg Infect Dis. 12(8):1209-1213.

Description:

Detecting beta-lactamase-mediated carbapenem resistance among Klebsiella pneumoniae isolates and other Enterobacteriaceae is an emerging problem. In t...

File Type:

[PDF - 105.46 KB]

File Type:

[PDF - 105.46 KB]
Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France

[PDF - 888.43 KB]

Personal Author:

Benzerara, Yahia ; Gallah, Salah ; ...

Published Date:

Sep 2017

Source:

Emerg Infect Dis. 23(9):1564-1567.

Description:

FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the cause of enzymatic resistance to fosfomycin. We show that mult...

File Type:

[PDF - 888.43 KB]

File Type:

[PDF - 888.43 KB]

Asymmetry and aging of mycobacterial cells leads to variable growth and antibiotic susceptibility

Asymmetry and aging of mycobacterial cells leads to variable growth and antibiotic susceptibility

You May Also Like:

Have Questions?

CDC INFORMATION

CONNECT WITH CDC