Content
and Copyright
i
Asymmetry and aging of mycobacterial cells leads to variable growth and antibiotic susceptibility
-
Published Date:
Dec 15 2011
Publisher's site:Source:Science. 335(6064):100-104.
[PDF-1.98 MB]
Details:
-
Alternative Title:Science
-
Personal Author:
-
Description:Cells use both deterministic and stochastic mechanisms to generate cell-to-cell heterogeneity, which enables the population to better withstand environmental stress. Here we show that, within a clonal population of mycobacteria, there is deterministic heterogeneity in elongation rate that arises because mycobacteria grow in an unusual, unipolar fashion. Division of the asymmetrically growing mother cell gives rise to daughter cells that differ in elongation rate and size. Because the mycobacterial cell division cycle is governed by time, not cell size, rapidly elongating cells do not divide more frequently than slowly elongating cells. The physiologically distinct subpopulations of cells that arise through asymmetric growth and division are differentially susceptible to clinically important classes of antibiotics.
-
Subject:
-
Pubmed ID:22174129
-
Pubmed Central ID:PMC3397429
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
image/gif 
image/jpeg 
application/pdf 
text/plain 
image/gif 
image/jpeg 
image/gif 
image/jpeg 
image/gif 
image/jpeg
No Related Documents.
You May Also Like:
-
Published Date:Source:Description:File Type:[PDF - 393.81 KB]
File Type:[PDF - 393.81 KB]
Published Date:Source:Description:File Type:[PDF - 471.49 KB]
File Type:[PDF - 471.49 KB]
Published Date:Source:Description:File Type:[PDF - 232.64 KB]
File Type:[PDF - 232.64 KB]
Published Date:Source:Description:File Type:[PDF - 105.46 KB]
File Type:[PDF - 105.46 KB]
Published Date:Source:Description:File Type:[PDF - 131.73 KB]
File Type:[PDF - 131.73 KB]
Have Questions?
Visit CDC Info
Email
CDC-INFO
Open 24/7
CDC INFORMATION
CONNECT WITH CDC
