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Asymmetry and aging of mycobacterial cells leads to variable growth and antibiotic susceptibility
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Dec 15 2011
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Source: Science. 335(6064):100-104.
[PDF-1.98 MB]
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Alternative Title:Science
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Description:Cells use both deterministic and stochastic mechanisms to generate cell-to-cell heterogeneity, which enables the population to better withstand environmental stress. Here we show that, within a clonal population of mycobacteria, there is deterministic heterogeneity in elongation rate that arises because mycobacteria grow in an unusual, unipolar fashion. Division of the asymmetrically growing mother cell gives rise to daughter cells that differ in elongation rate and size. Because the mycobacterial cell division cycle is governed by time, not cell size, rapidly elongating cells do not divide more frequently than slowly elongating cells. The physiologically distinct subpopulations of cells that arise through asymmetric growth and division are differentially susceptible to clinically important classes of antibiotics.
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Pubmed ID:22174129
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Pubmed Central ID:PMC3397429
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Volume:335
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Issue:6064
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