Details:

Alternative Title:
Cancer Causes Control
Publisher's site:
http://dx.doi.org/10.1007/s10552-012-9976-z
Personal Author:
Friesen, Melissa C. ; Betenia, Nicole ; Costello, Sadie ; Eisen, Ellen A.
Friesen, Melissa C. ; Betenia, Nicole ; Costello, Sadie ; Eisen, Ellen A. Less -
Description:
Objectives

Metalworking fluids (MWFs) have been associated with cancer of several sites, but the risks have been primarily examined in men or in studies that adjusted for gender in analyses. To evaluate whether risks were similar in women, we report cancer mortality risk among 4,825 female autoworkers within the united autoworkers–general motors autoworkers cohort.

Methods

Standardized mortality rates (SMRs) were calculated based on Michigan death rates (1980–2004). Internal comparisons (1941–2004) were examined using Cox regression for straight, soluble, and synthetic MWFs, and their corresponding oil- and water-based fractions.

Results

MWF exposure levels in the female cohort were generally less than two-third the MWF levels in the male cohort. Female autoworkers had an excess of cancer from all sites (SMR, 1.10; 95 % confidence interval (CI), 0.98–1.22) and lung cancer (SMR, 2.08; 95 % CI, 1.71–2.52). Colon cancer risk increased with straight (mineral oil) MWF exposure (exposure>median; hazard ratio = 3.1; 95 % CI, 1.2–8.0). A protective effect was observed for ovarian cancer with the soluble MWFs and water-based MWF metrics. Although bladder, rectal, and laryngeal cancers and malignant melanoma have been associated with straight MWF exposure and pancreatic cancer with synthetic MWF in men, there were too few deaths in this female subcohort to examine exposure-response relations for these sites. Results were null for lung and breast cancer.

Conclusions

Our findings support an association between colon cancer and straight MWFs, but we found limited evidence of risk for other tumor sites at the lower exposure levels experienced by the female autoworkers.


Subject:
[+]
Aged
Article
Automobiles
Cancer Mortality
Cohort Studies
Colon Cancer
Female
Humans
Hydrocarbons, Chlorinated
Industrial Oils
Male
Metals
Metalworking Fluids
Middle Aged
Neoplasms
Occupational Diseases
Occupational Exposure
Retrospective Studies
Risk Assessment
Risk Factors
Survival Rate
Women's Health
Women's Health

Source:
Cancer Causes Control. 2012; 23(7):1075-1082.
Pubmed ID:
22562220
Pubmed Central ID:
PMC3370111
Document Type:
Journal Article
Funding:
R01 OH008927/OH/NIOSH CDC HHS/United States ; Z99 CA999999/Intramural NIH HHS/United States ; ZIA CP010123-15/Intramural NIH HHS/United States
R01 OH008927/OH/NIOSH CDC HHS/United States ; Z99 CA999999/Intramural NIH HHS/United States ; ZIA CP010123-15/Intramural NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f5f1deebe24851663a37c52226c56de161f354c7ff93036cf4944244e7bea8c6
File Type:

Supporting Files

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