Genetics of Atherosclerosis

Lusis, Aldons J.

doi:10.1016/j.tig.2012.03.001

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Genetics of Atherosclerosis

Published Date:

Apr 03 2012

Publisher's site:

http://dx.doi.org/10.1016/j.tig.2012.03.001 New Site Icon

Source:

Trends Genet. 2012; 28(6):267-275.

[PDF-1.90 MB]

Details:

Personal Authors:

Lusis, Aldons J.

Keywords:

[+]

Pubmed ID:

22480919

Pubmed Central ID:

PMC3362664

Description:

Genome-wide association studies (GWAS) from the past several years have provided the first unbiased evidence of the genes contributing to common cardiovascular disease traits in European and some Asian populations. The results not only confirmed the importance of prior knowledge, such as the central role of lipoproteins, but also revealed that there is still much to learn about the underlying mechanisms of this disease, as most of the associated genes do not appear to be involved in pathways previously connected to atherosclerosis. In this review, I focus on the common forms of the disease and look at both human and animal model studies. I summarize what was known before GWAS, highlight how the field has been changed by GWAS, and discuss future considerations, such as the limitations of GWAS and strategies that may lead to a more complete, mechanistic understanding of atherosclerosis.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Main Document Checksum:

[+]

Supporting Files:

	nihms-368355.nxml	application/octet-stream
	nihms-368355-f0001.gif	image/gif
	nihms-368355-f0001.jpg	image/jpeg
	nihms-368355-f0002.gif	image/gif
	nihms-368355-f0002.jpg	image/jpeg
	nihms-368355-f0003.gif	image/gif
	nihms-368355-f0003.jpg	image/jpeg
	nihms-368355-f0004.gif	image/gif
	nihms-368355-f0004.jpg	image/jpeg

No Related Documents.

You May Also Like:

Genetics of Common Forms of Heart Disease

Personal Author:

Welch, Carrie; Lusis, Aldons J.;

Published:

Oct 12 2013

Source:

Circ Res. 2013; 113(9):1035-1036.

File Type:

[PDF - 83.38 KB]
Gene polymorphisms in association with self-reported stroke in US adults

Personal Author:

Fan, Amy Z.; Fang, Jing; Yesupriya, Ajay; Chang, Man-huei; Kilmer, Greta; House, Meaghan; Hayes, Donald; Ned, Renée M.; Dowling, Nicole F.; Mokdad, Ali H.;

Published:

Mar 11 2010

Source:

Appl Clin Genet. 2010; 3:23-28.

Description:

Purpose : Epidemiologic studies suggest that several gene variants increase the risk of stroke, and population-based studies help provide further evidence. We identified polymorphisms associated with the prevalence of self-reported stroke in US popul...

File Type:

[PDF - 160.51 KB]
ADRB2 Arg16Gly Polymorphism, Lung Function, and Mortality: Results from the Atherosclerosis Risk in Communities Study

Personal Author:

Ferdinands, Jill M.; Mannino, David M.; Gwinn, Marta L.; Bray, Molly S.;

Published:

Mar 14 2007

Source:

PLoS ONE. 2007; 2(3).

Description:

Background : Growing evidence suggests that the Arg16Arg genotype of the beta-2 adrenergic receptor gene may be associated with adverse effects of beta-agonist therapy. We sought to examine the association of beta-agonist use and the Arg16Gly polymor...

File Type:

[PDF - 180.19 KB]
Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

Personal Author:

Chang, Man-huei; Yesupriya, Ajay; Ned, Renée M.; Mueller, Patricia W.; Dowling, Nicole F.;

Published:

Apr 20 2010

Source:

BMC Med Genet. 2010; 11:62.

Description:

Background : The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major...

File Type:

[PDF - 1.28 MB]
Gene polymorphisms in association with emerging cardiovascular risk markers in adult women

Personal Author:

Fan, Amy Z.; Yesupriya, Ajay; Chang, Man-huei; House, Meaghan; Fang, Jing; Ned, Renée M.; Hayes, Donald; Dowling, Nicole F.; Mokdad, Ali H.;

Published:

Jan 15 2010

Source:

BMC Med Genet. 2010; 11:6.

Description:

Background : Evidence on the associations of emerging cardiovascular disease risk factors/markers with genes may help identify intermediate pathways of disease susceptibility in the general population. This population-based study is aimed to determin...

File Type:

[PDF - 245.87 KB]