Disease-Associated Streptococcus pneumoniae Genetic Variation

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Yang, Shimin ; Chen, Jianyu ; Fu, Jinjian ; Huang, Jiayin ; Li, Ting ; Yao, Zhenjiang ; Ye, Xiaohua
• Description:
  Streptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carriage isolates to address genomic variation associated with pathogenicity. We identified 8 consensus k-mers associated with adherence, antimicrobial resistance, and immune modulation, which were unevenly distributed in the infection isolates. Classification accuracy of the best k-mer predictor for S. pneumoniae infection was good, giving a simple target for predicting pathogenic isolates. Our findings suggest that S. pneumoniae pathogenicity is complex and multifactorial, and we provide genetic evidence for precise targeted interventions.
• Subjects:
  Biological Evolution Child Genetic Variation Genome-Wide Association Study Humans
• Keywords:
  Bacteria Bacterial Genomes Genome-wide Association Study Pathogenicity Streptococcus Pneumoniae
• Source:
  Emerg Infect Dis. 2024; 30(1):39-49
• Pubmed ID:
  38146979
• Pubmed Central ID:
  PMC10756394
• Document Type:
  Journal Article
• Place as Subject:
  China
• Volume:
  30
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bea3a85e31cec93bd3b9c65ada0cfc6f3594c762f008ae7dac89dfeb58352cfa
• Download URL:
  https://stacks.cdc.gov/view/cdc/140560/cdc_140560_DS1.pdf
• File Type:
  [PDF - 3.55 MB ]