Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles

Parrott, Matthew C.; Finniss, Mathew; Luft, J. Chris; Pandya, Ashish; Gullapalli, Anuradha; Napier, Mary E.; DeSimone, Joseph M.

doi:10.1021/ja301710z

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Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles

Published Date:

Apr 30 2012

Publisher's site:

http://dx.doi.org/10.1021/ja301710z New Site Icon

Source:

J Am Chem Soc. 134(18):7978-7982.

[PDF-1.59 MB]

Details:

Personal Authors:

Parrott, Matthew C. ; Finniss, Mathew ; Luft, J. Chris ; Pandya, Ashish ; Gullapalli, Anuradha ; ... More ▼

Keywords:

[+]

Pubmed ID:

22545784

Pubmed Central ID:

PMC3362319

Description:

Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water-soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and, therefore, the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1DP10D006432-01/DP/NCCDPHP CDC HHS/United States
1R01EB009565-02/EB/NIBIB NIH HHS/United States
DP1 CA174425/CA/NCI NIH HHS/United States
R01 EB009565/EB/NIBIB NIH HHS/United States
U54 CA119343/CA/NCI NIH HHS/United States
U54 CA151652/CA/NCI NIH HHS/United States
U54CA119373/CA/NCI NIH HHS/United States
U54CA151652/CA/NCI NIH HHS/United States

Supporting Files:

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