Details:

Alternative Title:
J Am Chem Soc
Publisher's site:
http://dx.doi.org/10.1021/ja301710z
Personal Author:
Parrott, Matthew C. ; Finniss, Mathew ; Luft, J. Chris ; Pandya, Ashish ; Gullapalli, Anuradha ; ... More +
Parrott, Matthew C. ; Finniss, Mathew ; Luft, J. Chris ; Pandya, Ashish ; Gullapalli, Anuradha ; Napier, Mary E. ; DeSimone, Joseph M. Less -
Description:
Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water-soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and, therefore, the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.
Subjects:
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Antineoplastic Agents Apoptosis Article Camptothecin Cell Line, Tumor Dasatinib Delayed-Action Preparations Deoxycytidine Ethers Humans Nanoparticles Neoplasms Prodrugs Pyrimidines Silanes Thiazoles
Source:
J Am Chem Soc. 134(18):7978-7982.
Pubmed ID:
22545784
Pubmed Central ID:
PMC3362319
Document Type:
Journal Article
Funding:
U54 CA119343/CA/NCI NIH HHS/United States ; 1R01EB009565-02/EB/NIBIB NIH HHS/United States ; R01 EB009565/EB/NIBIB NIH HHS/United States ; U54CA119373/CA/NCI NIH HHS/United States ; 1DP10D006432-01/DP/NCCDPHP CDC HHS/United States ; ... More +
U54 CA119343/CA/NCI NIH HHS/United States ; 1R01EB009565-02/EB/NIBIB NIH HHS/United States ; R01 EB009565/EB/NIBIB NIH HHS/United States ; U54CA119373/CA/NCI NIH HHS/United States ; 1DP10D006432-01/DP/NCCDPHP CDC HHS/United States ; DP1 CA174425/CA/NCI NIH HHS/United States ; U54CA151652/CA/NCI NIH HHS/United States ; U54 CA151652/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e29aad1327f6d20788c8777d296d9063b6281a05e4bf5512653b75d68f410ad4
Download URL:
https://stacks.cdc.gov/view/cdc/33375/cdc_33375_DS1.pdf
File Type:

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