Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles

Parrott, Matthew C.; Finniss, Mathew; Luft, J. Chris; Pandya, Ashish; Gullapalli, Anuradha; Napier, Mary E.; DeSimone, Joseph M.

doi:10.1021/ja301710z

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Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles

Published Date:

Apr 30 2012

Publisher's site:

http://dx.doi.org/10.1021/ja301710z New Site Icon

Source:

J Am Chem Soc. 134(18):7978-7982.

[PDF-1.59 MB]

Details:

Alternative Title:

J Am Chem Soc

Personal Author:

Parrott, Matthew C. ; Finniss, Mathew ; Luft, J. Chris ; Pandya, Ashish ; Gullapalli, Anuradha ; ... More ▼

Description:

Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water-soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and, therefore, the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.

Subject:

[+]

Pubmed ID:

22545784

Pubmed Central ID:

PMC3362319

Document Type:

Journal Article

Funding:

U54 CA119343/CA/NCI NIH HHS/United States ; 1R01EB009565-02/EB/NIBIB NIH HHS/United States ; R01 EB009565/EB/NIBIB NIH HHS/United States ; U54CA119373/CA/NCI NIH HHS/United States ; 1DP10D006432-01/DP/NCCDPHP CDC HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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