Details:

Alternative Title:
J Am Chem Soc
Publisher's site:
http://dx.doi.org/10.1021/ja301710z
Personal Author:
Parrott, Matthew C. ; Finniss, Mathew ; Luft, J. Chris ; Pandya, Ashish ; Gullapalli, Anuradha ; ... More +
Parrott, Matthew C. ; Finniss, Mathew ; Luft, J. Chris ; Pandya, Ashish ; Gullapalli, Anuradha ; Napier, Mary E. ; DeSimone, Joseph M. ; Less -
Description:
Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water-soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and, therefore, the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.
Subject:
[+]
Antineoplastic Agents
Apoptosis
Article
Camptothecin
Cell Line, Tumor
Dasatinib
Delayed-Action Preparations
Deoxycytidine
Ethers
Humans
Nanoparticles
Neoplasms
Prodrugs
Pyrimidines
Silanes
Thiazoles

Source:
J Am Chem Soc. 134(18):7978-7982. ;
Pubmed ID:
22545784
Pubmed Central ID:
PMC3362319
Document Type:
Journal Article ;
Funding:
U54 CA119343/CA/NCI NIH HHS/United States ; 1R01EB009565-02/EB/NIBIB NIH HHS/United States ; R01 EB009565/EB/NIBIB NIH HHS/United States ; U54CA119373/CA/NCI NIH HHS/United States ; 1DP10D006432-01/DP/NCCDPHP CDC HHS/United States ; ... More +
U54 CA119343/CA/NCI NIH HHS/United States ; 1R01EB009565-02/EB/NIBIB NIH HHS/United States ; R01 EB009565/EB/NIBIB NIH HHS/United States ; U54CA119373/CA/NCI NIH HHS/United States ; 1DP10D006432-01/DP/NCCDPHP CDC HHS/United States ; DP1 CA174425/CA/NCI NIH HHS/United States ; U54CA151652/CA/NCI NIH HHS/United States ; U54 CA151652/CA/NCI NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e29aad1327f6d20788c8777d296d9063b6281a05e4bf5512653b75d68f410ad4
File Type:

Supporting Files

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