Neurocognitive Outcomes in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study

Details

• Alternative Title:
  J Am Acad Child Adolesc Psychiatry
• Personal Author:
  Frazier, Jean A. ; Giuliano, Anthony J. ; Johnson, Jacqueline L. ; Yakutis, Lauren ; Youngstrom, Eric A. ; Breiger, David ; Sikich, Linmarie ; Findling, Robert L. ; McClellan, Jon ; Hamer, Robert M. ; Vitiello, Benedetto ; Lieberman, Jeffrey A. ; Hooper, Stephen R.
• Description:
  Objective
  
  To assess neurocognitive outcomes following antipsychotic intervention in youth enrolled in the National Institute of Mental Health (NIMH)-funded Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS).
  
  Method
  
  Neurocognitive functioning of youth (ages 8–19 years) with schizophrenia or schizoaffective disorder was evaluated in a four-site randomized, double-blind clinical trial comparing molindone, olanzapine or risperidone. The primary outcomes were overall group change from baseline in neurocognitive composite and six domain scores after 8 weeks and continued treatment up to 52 weeks. Age and sex were included as covariates in all analyses.
  
  Results
  
  Seventy-seven of 116 TEOSS participants (66%) had post-baseline neurocognitive data. No significant differences emerged in the neurocognitive outcomes of the three medication groups. Therefore, the three treatment groups were combined into one group to assess overall neurocognitive outcomes. Significant modest improvements were observed in the composite score and in three of six domain scores in the acute phase, and in four of six domain scores in the combined acute and maintenance phases. Partial correlation analyses revealed very few relationships among Positive and Negative Syndrome Scale (PANSS) baseline or change scores and neurocognition change scores.
  
  Conclusions
  
  Antipsychotic intervention in youth with early-onset schizophrenia spectrum disorders (EOSS) led to modest improvement in measures of neurocognitive function. The changes in cognition were largely unrelated to baseline symptoms or symptom change. Small treatment effect sizes, easily accounted for by practice effects, highlight the critical need for the development of more efficacious interventions for the enduring neurocognitive deficits seen in EOSS.
  
  
• Subjects:
  Adolescent Antipsychotic Agents Benzodiazepines Child Cognition Disorders Double-Blind Method Female Follow-Up Studies Humans Male Molindone Neuropsychological Tests Psychotic Disorders Risperidone Schizophrenia Schizophrenic Psychology

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• Source:
  J Am Acad Child Adolesc Psychiatry. 2012; 51(5):496-505.
• Pubmed ID:
  22525956
• Pubmed Central ID:
  PMC3337647
• Document Type:
  Journal Article
• Funding:
  90DD043003/DD/NCBDD CDC HHS/United States ; M01-RR00037/RR/NCRR NIH HHS/United States ; MCJ379154A/PHS HHS/United States ; MH01-RR00046/MH/NIMH NIH HHS/United States ; P30 HD004147/HD/NICHD NIH HHS/United States ; R01 MH073801/MH/NIMH NIH HHS/United States ; R01 MH073967/MH/NIMH NIH HHS/United States ; U01 MH061355/MH/NIMH NIH HHS/United States ; U01 MH061355-01A1/MH/NIMH NIH HHS/United States ; U01 MH061464/MH/NIMH NIH HHS/United States ; U01 MH061464-01A1/MH/NIMH NIH HHS/United States ; U01 MH061528/MH/NIMH NIH HHS/United States ; U01 MH061528-04/MH/NIMH NIH HHS/United States ; U01 MH062726/MH/NIMH NIH HHS/United States ; U01 MH062726-01/MH/NIMH NIH HHS/United States ; U01MH61355/MH/NIMH NIH HHS/United States ; U01MH61464/MH/NIMH NIH HHS/United States ; U01MH61528/MH/NIMH NIH HHS/United States ; U01MH62726/MH/NIMH NIH HHS/United States
• Volume:
  51
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:14094f4cf4be57b61322293fbee15f6ada2569f688853936cde141e99a770b19
• Download URL:
  https://stacks.cdc.gov/view/cdc/33351/cdc_33351_DS1.pdf
• File Type:
  [PDF - 833.50 KB ]