Agreement between Clinical Screening Procedures for Neuropathy in the Feet
Published Date:May 2012
Source:Muscle Nerve. 45(5):653-658.
Pubmed Central ID:PMC3335757
Funding:T32 007062/PHS HHS/United States
T32 ES007062/ES/NIEHS NIH HHS/United States
T32 ES007062-18/ES/NIEHS NIH HHS/United States
T42 OH008455-04/OH/NIOSH CDC HHS/United States
UL1 RR024986/RR/NCRR NIH HHS/United States
UL1 RR024986-02/RR/NCRR NIH HHS/United States
UL1RR024986/RR/NCRR NIH HHS/United States
The correlation between monofilament testing, symptom surveys and electrodiagnostic studies for the diagnosis of axonal polyneuropathy has not been well studied. This study was to assess the agreement between these procedures in a non-random sample of volunteers.
The evaluated procedures included electrodiagnostic tests of the sural nerve, monofilament testing of the great toe, a symptom survey and a body diagram. Kappa coefficients, sensitivity and specificity, using nerve conduction as a ‘gold standard’, were used to determine the agreement between various combinations of procedures.
Poor agreement (Kappa values: −0.12 ~ 0.44) and sensitivity (sensitivity<30%) were found for all combinations of symptoms and monofilament results in comparison with sural peak latency and amplitude.
Overall, the results demonstrated a low discriminatory power for the screening procedures for identifying persons with impaired sural nerve function. The results highlight the need for further development and evaluation of screening methods for distal neuropathy in population-based studies.
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