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Agreement between Clinical Screening Procedures for Neuropathy in the Feet
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May 2012
Source: Muscle Nerve. 45(5):653-658.
[PDF-289.36 KB]
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Alternative Title:Muscle Nerve
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Description:Introduction
The correlation between monofilament testing, symptom surveys and electrodiagnostic studies for the diagnosis of axonal polyneuropathy has not been well studied. This study was to assess the agreement between these procedures in a non-random sample of volunteers.
Methods
The evaluated procedures included electrodiagnostic tests of the sural nerve, monofilament testing of the great toe, a symptom survey and a body diagram. Kappa coefficients, sensitivity and specificity, using nerve conduction as a ‘gold standard’, were used to determine the agreement between various combinations of procedures.
Results
Poor agreement (Kappa values: −0.12 ~ 0.44) and sensitivity (sensitivity<30%) were found for all combinations of symptoms and monofilament results in comparison with sural peak latency and amplitude.
Discussion
Overall, the results demonstrated a low discriminatory power for the screening procedures for identifying persons with impaired sural nerve function. The results highlight the need for further development and evaluation of screening methods for distal neuropathy in population-based studies.
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Pubmed ID:22499091
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Pubmed Central ID:PMC3335757
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