Agreement between Clinical Screening Procedures for Neuropathy in the Feet

Details

• Alternative Title:
  Muscle Nerve
• Personal Author:
  Wang, Yi ; Goodrich, Jaclyn M. ; Werner, Robert ; Gillespie, Brenda ; Basu, Niladri ; Franzblau, Alfred
• Description:
  Introduction
  
  The correlation between monofilament testing, symptom surveys and electrodiagnostic studies for the diagnosis of axonal polyneuropathy has not been well studied. This study was to assess the agreement between these procedures in a non-random sample of volunteers.
  
  Methods
  
  The evaluated procedures included electrodiagnostic tests of the sural nerve, monofilament testing of the great toe, a symptom survey and a body diagram. Kappa coefficients, sensitivity and specificity, using nerve conduction as a ‘gold standard’, were used to determine the agreement between various combinations of procedures.
  
  Results
  
  Poor agreement (Kappa values: −0.12 ~ 0.44) and sensitivity (sensitivity<30%) were found for all combinations of symptoms and monofilament results in comparison with sural peak latency and amplitude.
  
  Discussion
  
  Overall, the results demonstrated a low discriminatory power for the screening procedures for identifying persons with impaired sural nerve function. The results highlight the need for further development and evaluation of screening methods for distal neuropathy in population-based studies.
  
  
• Subjects:
  Agreement Article Diabetes Mellitus Electric Stimulation Electrodiagnosis Female Foot Humans Male Monofilament Nerve Conduction Neural Conduction Polyneuropathies Reaction Time Retrospective Studies Sensitivity And Specificity Sural Nerve Surveys And Questionnaires Symptom

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• Source:
  Muscle Nerve. 45(5):653-658.
• Pubmed ID:
  22499091
• Pubmed Central ID:
  PMC3335757
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHS/United States ; T32 ES007062-18/ES/NIEHS NIH HHS/United States ; UL1RR024986/RR/NCRR NIH HHS/United States ; T42 OH008455-04/OH/NIOSH CDC HHS/United States ; UL1 RR024986-02/RR/NCRR NIH HHS/United States ; T32 ES007062/ES/NIEHS NIH HHS/United States ; UL1 RR024986/RR/NCRR NIH HHS/United States ; T32 007062/PHS HHS/United States
• Volume:
  45
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e7934528d3a6a1454ffc9f17ddb01ac60daa787cf1a52cb3ee72803bf4dce9f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/33349/cdc_33349_DS1.pdf
• File Type:
  [PDF - 289.36 KB ]