Agreement between clinical screening procedures for neuropathy in the feet

Details

• Personal Author:
  Basu N ; Franzblau, Alfred ; Gillespie B ; Goodrich JM ; Wang Y ; Werner R
• Description:
  INTRODUCTION: The correlation between monofilament testing, symptom surveys, and electrodiagnostic studies for the diagnosis of axonal polyneuropathy has not been well studied. This investigation was done to assess the agreement between these procedures in a non-random sample of volunteers. METHODS: The procedures evaluated included electrodiagnostic tests of the sural nerve, monofilament testing of the great toe, a symptom survey, and a body diagram. Kappa coefficients and sensitivity and specificity, using nerve conduction as a "gold standard," were used to determine the agreement between various combinations of procedures. RESULTS: Poor agreement (kappa values -0.12-0.44) and sensitivity (sensitivity <30%) were found for all combinations of symptoms and monofilament results in comparison with sural peak latency and amplitude. CONCLUSIONS: Overall, the results demonstrated a low discriminatory power for the screening procedures for identifying persons with impaired sural nerve function. The results highlight the need for further development and evaluation of screening methods for distal neuropathy in population-based studies. [Description provided by NIOSH]
• Subjects:
  Blood Diagnosis Electrophysiology Hematologic Diseases Men Musculoskeletal Diseases Musculoskeletal System Nervous System Occupational Health Pathology Safety Surveys And Questionnaires Women

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• Keywords:
  Author Keywords: Agreement Blood-sugar-disorders Clinical-diagnosis Clinical-symptoms Diagnostic-tests Electrophysiological-examinations Foot-disorders Health-surveys Humans Medical-screening Medical-surveys Monofilament Nerve-function Nerve Conduction Neuromotor-activity Neuropathy Neurophysiology Physiopathology Questionnaires Reaction-rates Sensitivity-testing Sural Nerve Symptom

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• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• Issue:
  5
• NIOSHTIC Number:
  nn:20040880
• Citation:
  Muscle Nerve 2012 May; 45(5):653-658
• Contact Point Address:
  Alfred Franzblau, MD, Department of Environmental Health Sciences, School of Public Health, University of Michigan, M1835 SPH I, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA
• Email:
  afranz@umich.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Muscle & Nerve
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:21645c6508741fdf1b4f85804adcdf2eb54d5028d5c721133d3a068b6e2e4836a58f24ac4fc0d458a97452f2707fb1c4b1cfe3637c1022c384ebda042a7e5acf
• Download URL:
  https://stacks.cdc.gov/view/cdc/193591/cdc_193591_DS1.pdf
• File Type:
  [PDF - 733.05 KB ]