An Investigation of Modifying Effects of Single Nucleotide Polymorphisms in Metabolism-related Genes on the Relationship between Peripheral Nerve Function and Mercury Levels in Urine and Hair

Details

• Alternative Title:
  Sci Total Environ
• Personal Author:
  Wang, Yi ; Goodrich, Jaclyn M. ; Werner, Robert ; Gillespie, Brenda ; Basu, Niladri ; Franzblau, Alfred
• Description:
  Mercury (Hg) is a potent neurotoxicant. We hypothesized that single nucleotide polymorphisms (SNPs) in genes coding glutathione-related proteins, selenoproteins and metallothioneins may modify the relationship of mercury biomarkers with changes in peripheral nerve function. Dental professionals (n=515) were recruited in 2009 and 2010. Sensory nerve function (onset latency, peak latency and amplitude) of the median, ulnar and sural nerves was recorded. Samples of urine, hair and DNA were collected. Covariates related to demographics, nerve function and elemental and methyl-mercury exposure were also collected. Subjects included 244 dentists (47.4%) and 269 non-dentists (52.2%; mostly dental hygienists and dental assistants). The mean mercury levels in urine (1.06 μg/L) and hair (0.51 μg/g) were not significantly different from the US general population (0.95 μg/L and 0.47 μg/g, respectively). In multivariate linear models predicting nerve function adjusting for covariates, only 3 out of a total of 504 models showed stable and statistically significant interaction of SNPs with mercury biomarkers. Overall, given the possibility of false positives, the results suggested little evidence of effect modification of the SNPs on the relationship between mercury biomarkers with peripheral nerve function at exposure levels that are relevant to the general US population.
• Subjects:
  Dental Assistants Dentists DNA Female Genotype Hair Humans Linear Models Male Mercury Poisoning, Nervous System Middle Aged Multivariate Analysis Neural Conduction Occupational Diseases Occupational Exposure Peripheral Nerves Polymerase Chain Reaction Polymorphism, Single Nucleotide Selenoproteins

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• Source:
  Sci Total Environ. 2012; 417-418:32-38
• Pubmed ID:
  22236634
• Pubmed Central ID:
  PMC3299006
• Document Type:
  Journal Article
• Funding:
  UL1 RR024986-05/RR/NCRR NIH HHS/United States ; T42 OH008455/OH/NIOSH CDC HHS/United States ; T42 OH 008455-04/OH/NIOSH CDC HHS/United States ; UL1RR024986/RR/NCRR NIH HHS/United States ; P30 ES017885/ES/NIEHS NIH HHS/United States ; T32 ES007062/ES/NIEHS NIH HHS/United States ; UL1 RR024986/RR/NCRR NIH HHS/United States ; T32 007062/PHS HHS/United States
• Place as Subject:
  United States
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:15d6a056c0bd313a13c3a9e902b083495a361fe1cfeae6134d778a293804bf89
• Download URL:
  https://stacks.cdc.gov/view/cdc/33320/cdc_33320_DS1.pdf
• File Type:
  [PDF - 336.17 KB ]