Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/ehp.1104079
Personal Author:
Wang, Yi ; Goodrich, Jaclyn M. ; Gillespie, Brenda ; Werner, Robert ; Basu, Niladri ; ... More +
Wang, Yi ; Goodrich, Jaclyn M. ; Gillespie, Brenda ; Werner, Robert ; Basu, Niladri ; Franzblau, Alfred ; Less -
Description:
Recent studies have suggested that several genes that mediate mercury metabolism are polymorphic in humans.|We hypothesized that single-nucleotide polymorphisms (SNPs) in metallothionein (MT) genes may underlie interindividual differences in mercury biomarker levels. We studied the potential modifying effects of MT SNPs on mercury exposure-biomarker relationships.|We measured total mercury in urine and hair samples of 515 dental professionals. We also surveyed occupational and personal exposures to dental amalgam and dietary fish consumption, from which daily methylmercury (MeHg) intake was estimated. Log-transformed urine and hair levels were modeled in multivariable linear regression separately against respective exposure surrogates, and the effect modification of 13 MT SNPs on exposure was investigated.|The mean mercury levels in urine (1.06 μg/L) and hair (0.51 μg/g) were not significantly different from the U.S. general population (0.95 μg/L and 0.47 μg/g, respectively). The mean estimated daily MeHg intake was 0.084 μg/kg/day (range, 0-0.98 μg/kg/day), with 25% of study population intakes exceeding the current U.S. Environmental Protection Agency reference dose of 0.1 μg/kg/day. Multivariate regression analysis showed that subjects with the MT1M (rs2270837) [corrected] AA genotype (n = 10) or the MT2A (rs10636) CC genotype (n = 42) had lower urinary mercury levels than did those with the MT1M or MT2A GG genotype (n = 329 and 251, respectively) after controlling for exposure and potential confounders. After controlling for MeHg intake, subjects with MT1A (rs8052394) GA and GG genotypes (n = 24) or the MT1M (rs9936741) TT genotype (n = 459) had lower hair mercury levels than did subjects with MT1A AA (n = 113) or MT1M TC and CC genotypes (n = 15), respectively.|Our findings suggest that some MT genetic polymorphisms may influence mercury biomarker concentrations at levels of exposure relevant to the general population.
Subject:
[+]
Adult
Aged
Animals
Biological Markers
Biomarker
Dental Amalgam
Dental Staff
Dentists
Environmental Exposure
Female
Fishes
Gene–environment Interaction
Hair
Humans
Linear Models
Male
Mercury
Metallothionein
Methylmercury Compounds
Michigan
Middle Aged
Multivariate Analysis
Occupational Exposure
Polymorphism, Single Nucleotide
Questionnaires
Research
Single-nucleotide Polymorphism
Species Specificity
Mercury
Metallothionein

Source:
Environ Health Perspect. 2012; 120(4):530-534.
Pubmed ID:
22233731
Pubmed Central ID:
PMC3339459
Document Type:
Journal Article ;
Funding:
T32 007062/PHS HHS/United States ; T32 ES007062/ES/NIEHS NIH HHS/United States ; T42 OH 008455-04/OH/NIOSH CDC HHS/United States ; UL1 RR024986/RR/NCRR NIH HHS/United States ; UL1RR024986/RR/NCRR NIH HHS/United States ;
T32 007062/PHS HHS/United States ; T32 ES007062/ES/NIEHS NIH HHS/United States ; T42 OH 008455-04/OH/NIOSH CDC HHS/United States ; UL1 RR024986/RR/NCRR NIH HHS/United States ; UL1RR024986/RR/NCRR NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2ad928401326c6573da667c6eec84aa929c06df755c711e898e1689e8dafe011
File Type:

Supporting Files

• 	ehp.1104079.e001.jpg	jpeg
  	ehp.1104079.nxml	txt
  	ehp.1104079.s001.pdf	pdf
  	license.txt	txt

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