Passive immune neutralization strategies for prevention and control of influenza A infections

Ye, Jianqiang; Shao, Hongxia; Perez, Daniel R

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Passive immune neutralization strategies for prevention and control of influenza A infections

Supporting Files

Feb 2012
By Ye, Jianqiang ; Shao, Hongxia ; Perez, Daniel R

File Language:

English

Details

Alternative Title:

Immunotherapy
Personal Author:

Ye, Jianqiang ; Shao, Hongxia ; Perez, Daniel R
Description:

Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses.
Subjects:

Animals Article Human Monoclonal Antibody Humans Immunization, Passive Immunoprophylaxis Immunotherapy Influenza, Human Influenza A Virus Influenza In Birds Influenza Vaccines Neutralizing Antibodies Pandemics Poultry Seasons
Source:

Immunotherapy. 2012; 4(2):175-186
Pubmed ID:

22339460
Pubmed Central ID:

PMC3292042
Document Type:

Journal Article
Funding:

R01 AI052155-04/AI/NIAID NIH HHS/United States ; R01AI052155/AI/NIAID NIH HHS/United States ; U01 CI000355/CI/NCPDCID CDC HHS/United States ; 1U01CI000355/CI/NCPDCID CDC HHS/United States ; R01 AI052155/AI/NIAID NIH HHS/United States ; HHSN266200700010C/PHS HHS/United States ; HHSN266200700010C/AI/NIAID NIH HHS/United States
Volume:

4
Issue:

2
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:f9b5c09f3f1189affa490ed68c34ba20bac7e1a0e31b5ac1c330d4364584c691
Download URL:

https://stacks.cdc.gov/view/cdc/33314/cdc_33314_DS1.pdf
File Type:

[PDF - 153.50 KB ]

File Language:

English

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