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Breast Cancer Risk in Families with Cleft Lip and Palate
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Oct 28 2011
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Source: Ann Epidemiol. 2011; 22(1):37-42.
[PDF-295.04 KB]
Details:
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Alternative Title:Ann Epidemiol
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Personal Author:
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Description:PURPOSE
To test whether females in families with cleft lip and/or palate (CL/P) have increased breast cancer risk
METHODS
Using the Danish Facial Cleft Registry, females with CL/P, mothers of children with CL/P, and sisters to CL/P cases were identified for the Danish birth cohorts 1911 to 1975. These females were compared to a 5% random sample of these cohorts regarding the incidence and age of onset for breast cancer registered in the Danish Hospital Discharge Register 1977–2005.
RESULTS
Examining 48,404 person-years for 1,809 female CL/P cases (49 breast cancer cases) and 212,795 person-years for 7935 female relatives (188 breast cancer cases) we found no increased breast cancer risk for either CL/P cases (hazard ratio (HR) = 1.23, 95% confidence interval (CI): 0.92–1.63), mothers of children with CL/P (HR = 0.93, 95%, CI: 0.80–1.08), or sisters of CL/P cases (HR = 0.94, 95% CI: 0.55–1.60). Neither were there any significant differences in age of onset.
CONCLUSION
Both epidemiological and genetic studies have suggested common etiological factors for breast cancer and cleft lip and/or palate (CL/P). However, this population-based study was not able to confirm a general increase in breast cancer risk among females in families with CL/P.
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Pubmed ID:22037380
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Pubmed Central ID:PMC3237814
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Volume:22
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Issue:1
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