Breast Cancer Risk in Families with Cleft Lip and Palate
Published Date:Oct 28 2011
Source:Ann Epidemiol. 2011; 22(1):37-42.
Pubmed Central ID:PMC3237814
Funding:1R01DD000295/DD/NCBDD CDC HHS/United States
R01 DE0020895/DE/NIDCR NIH HHS/United States
R01 DE008559/DE/NIDCR NIH HHS/United States
R01 DE008559-14/DE/NIDCR NIH HHS/United States
R01 DE011948/DE/NIDCR NIH HHS/United States
R01 DE011948-07/DE/NIDCR NIH HHS/United States
R01 DE020895/DE/NIDCR NIH HHS/United States
R01 DE020895-03/DE/NIDCR NIH HHS/United States
R01 DE08559/DE/NIDCR NIH HHS/United States
R01 DE11948/DE/NIDCR NIH HHS/United States
R37 DE008559/DE/NIDCR NIH HHS/United States
To test whether females in families with cleft lip and/or palate (CL/P) have increased breast cancer risk
Using the Danish Facial Cleft Registry, females with CL/P, mothers of children with CL/P, and sisters to CL/P cases were identified for the Danish birth cohorts 1911 to 1975. These females were compared to a 5% random sample of these cohorts regarding the incidence and age of onset for breast cancer registered in the Danish Hospital Discharge Register 1977–2005.
Examining 48,404 person-years for 1,809 female CL/P cases (49 breast cancer cases) and 212,795 person-years for 7935 female relatives (188 breast cancer cases) we found no increased breast cancer risk for either CL/P cases (hazard ratio (HR) = 1.23, 95% confidence interval (CI): 0.92–1.63), mothers of children with CL/P (HR = 0.93, 95%, CI: 0.80–1.08), or sisters of CL/P cases (HR = 0.94, 95% CI: 0.55–1.60). Neither were there any significant differences in age of onset.
Both epidemiological and genetic studies have suggested common etiological factors for breast cancer and cleft lip and/or palate (CL/P). However, this population-based study was not able to confirm a general increase in breast cancer risk among females in families with CL/P.
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