Life stressors and 5-HTTLPR interaction in relation to mid-pregnancy depressive symptoms among African-American women

Details

• Alternative Title:
  Psychiatr Genet
• Personal Author:
  Scheid, Jeanette M. ; Holzman, Claudia B. ; Jones, Nicole ; Friderici, Karen H. ; Jernigan, Katherine A ; Symonds, Laura L. ; Sikorskii, Alla ; Fisher, Rachel
• Description:
  Objective
  
  In previous analyses of non-Hispanic white women we found a stronger relation between abuse history and mid-pregnancy elevated depressive symptoms in women with the serotonin transporter (5-HTTLPR) S/S genotype. Here we focus on African-American women (N=698). Our inquiry is motivated by racial differences in depression diagnosis/treatment, stressors and frequency of major 5-HTTLPR alleles (S, LA, LG).
  
  Methods
  
  Stressful life events (lifetime) and depressive symptoms (current) were ascertained at 15–27 weeks gestation. A Center for Epidemiological Studies Depression score of ≥18 was considered “elevated”. Life events were scored together and separated into six sub-constructs. 5-HTTLPR genotypes were grouped as follows: 1) L and S alleles, 2) S-LG equivalence (“tri- to biallelic”) and 3) LA/LA, all others, S/S (“high/intermediate/low”). Odds ratios (OR) for “elevated” depressive symptoms-life events (total and sub-constructs) relations were calculated for each genotype grouping.
  
  Results
  
  The prevalence of “elevated” depressive symptoms did not vary by genotype. The relation between stressful life events and “elevated” depressive symptoms was stronger in S/S compared to LA/LA genotype (interaction P=0.11). Of the six sub-constructs, only abuse showed a statistically significant gene-environment interaction. The OR for the abuse- “elevated” depressive symptoms association was greater for S/S vs. LA/LA (interaction P= 0.03) and in the “tri- to biallelic” grouping (interaction P=0.04). In the “high/intermediate/low” grouping, “low” (S/S) had a higher OR (5.5) than both “intermediate” and “high” (ORs≤2.3) (interaction P=0.10).
  
  Conclusions
  
  These results show the importance of examining racial groups, specific stressful events and different 5-HTTLPR genotype groupings when exploring gene-environment interactions in depression.
  
  
• Subjects:
  Adult Black Or African American Demography Depression Female Genotype Humans Life Change Events Odds Ratio Pregnancy Pregnancy Outcome Serotonin Plasma Membrane Transport Proteins Stress, Psychological Young Adult

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• Keywords:
  5-HTTLPR African American Depressive Symptoms Gender Gene-environment Interaction Pregnancy Stressful Life Events Women
• Source:
  Psychiatr Genet. 21(6):271-280
• Pubmed ID:
  22030619
• Pubmed Central ID:
  PMC3205426
• Document Type:
  Journal Article
• Funding:
  T32 HD046377/HD/NICHD NIH HHSUnited States/ ; R01 HD034543-06/HD/NICHD NIH HHSUnited States/ ; T32 HD046377-05/HD/NICHD NIH HHSUnited States/ ; R01 HD034543-04/HD/NICHD NIH HHSUnited States/ ; R01 HD034543-07/HD/NICHD NIH HHSUnited States/ ; R01 HD034543/HD/NICHD NIH HHSUnited States/ ; R01 HD034543-05A1/HD/NICHD NIH HHSUnited States/ ; R01 HD34543-01/HD/NICHD NIH HHSUnited States/ ; T32 HD046377-06/HD/NICHD NIH HHSUnited States/ ; R01 HD034543-08/HD/NICHD NIH HHSUnited States/ ; R01 HD034543-07S1/HD/NICHD NIH HHSUnited States/ ; U01 DP000143/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000143-02/DP/NCCDPHP CDC HHSUnited States/ ; R01 HD034543-03/HD/NICHD NIH HHSUnited States/
• Volume:
  21
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:723eaa650b9bae8d5adab025a25727ac5e3779d914a1a53e7020e18325e9f6cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/33266/cdc_33266_DS1.pdf
• File Type:
  [PDF - 463.89 KB ]