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Life stressors and 5-HTTLPR interaction in relation to mid-pregnancy depressive symptoms among African-American women
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Details:
  • Pubmed ID:
    22030619
  • Pubmed Central ID:
    PMC3205426
  • Description:
    Objective

    In previous analyses of non-Hispanic white women we found a stronger relation between abuse history and mid-pregnancy elevated depressive symptoms in women with the serotonin transporter (5-HTTLPR) S/S genotype. Here we focus on African-American women (N=698). Our inquiry is motivated by racial differences in depression diagnosis/treatment, stressors and frequency of major 5-HTTLPR alleles (S, LA, LG).

    Methods

    Stressful life events (lifetime) and depressive symptoms (current) were ascertained at 15–27 weeks gestation. A Center for Epidemiological Studies Depression score of ≥18 was considered “elevated”. Life events were scored together and separated into six sub-constructs. 5-HTTLPR genotypes were grouped as follows: 1) L and S alleles, 2) S-LG equivalence (“tri- to biallelic”) and 3) LA/LA, all others, S/S (“high/intermediate/low”). Odds ratios (OR) for “elevated” depressive symptoms-life events (total and sub-constructs) relations were calculated for each genotype grouping.

    Results

    The prevalence of “elevated” depressive symptoms did not vary by genotype. The relation between stressful life events and “elevated” depressive symptoms was stronger in S/S compared to LA/LA genotype (interaction P=0.11). Of the six sub-constructs, only abuse showed a statistically significant gene-environment interaction. The OR for the abuse- “elevated” depressive symptoms association was greater for S/S vs. LA/LA (interaction P= 0.03) and in the “tri- to biallelic” grouping (interaction P=0.04). In the “high/intermediate/low” grouping, “low” (S/S) had a higher OR (5.5) than both “intermediate” and “high” (ORs≤2.3) (interaction P=0.10).

    Conclusions

    These results show the importance of examining racial groups, specific stressful events and different 5-HTTLPR genotype groupings when exploring gene-environment interactions in depression.

  • Document Type:
  • Collection(s):
  • Funding:
    R01 HD034543-03/HD/NICHD NIH HHS/United States
    R01 HD034543-04/HD/NICHD NIH HHS/United States
    R01 HD034543-05A1/HD/NICHD NIH HHS/United States
    R01 HD034543-06/HD/NICHD NIH HHS/United States
    R01 HD034543-07/HD/NICHD NIH HHS/United States
    R01 HD034543-07/HD/NICHD NIH HHS/United States
    R01 HD034543-07S1/HD/NICHD NIH HHS/United States
    R01 HD034543-08/HD/NICHD NIH HHS/United States
    R01 HD34543-01/HD/NICHD NIH HHS/United States
    T32 HD046377/HD/NICHD NIH HHS/United States
    T32 HD046377-05/HD/NICHD NIH HHS/United States
    T32 HD046377-06/HD/NICHD NIH HHS/United States
    U01 DP000143-02/DP/NCCDPHP CDC HHS/United States
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