Details:

Alternative Title:
Dev Psychopathol
Personal Author:
LEI, MAN-KIT ; SIMONS, RONALD L. ; EDMOND, MARY BOND ; SIMONS, LESLIE GORDON ; CUTRONA, CAROLYN E. ;
LEI, MAN-KIT ; SIMONS, RONALD L. ; EDMOND, MARY BOND ; SIMONS, LESLIE GORDON ; CUTRONA, CAROLYN E. ; Less -
Description:
Social disorganization theory posits that individuals who live in disadvantaged neighborhoods are more likely to engage in antisocial behavior than are those who live in advantaged neighborhoods and that neighborhood disadvantage asserts this effect through its disruptive impact on social ties. Past research on this framework has been limited in two respects. First, most studies have concentrated on adolescent males. In contrast, the present study focused on a sample of adult African American females. Second, past research has largely ignored individual-level factors that might explain why people who grow up in disadvantaged neighborhoods often do not engage in antisocial behavior. We investigated the extent to which genetic variation contributes to heterogeneity of response to neighborhood conditions. We found that the impact of neighborhood disadvantage on antisocial behavior was mediated by neighborhood social ties. Further, the analysis indicated that the effects of neighborhood disadvantage and social ties on antisocial behavior were moderated by genetic polymorphisms. Examination of these moderating effects provided support for the differential susceptibility model of Gene × Environment. The effect of Gene × Neighborhood Disadvantage on antisocial behavior was mediated by the effect of Gene × Neighborhood Social Ties, providing support for an expanded view of social disorganization theory.
Subject:
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Adolescent
Adult
African Americans
Antisocial Personality Disorder
Article
Child
Female
Gene-Environment Interaction
Genetic Variation
Humans
Interview, Psychological
Longitudinal Studies
Male
Receptors, Dopamine D4
Residence Characteristics
Serotonin Plasma Membrane Transport Proteins
Social Support
Vulnerable Populations
Young Adult

Source:
Dev Psychopathol. 26(4 0 1):1113-1128
Pubmed ID:
24713449
Pubmed Central ID:
PMC4527049
Document Type:
Journal Article ;
Funding:
R01 AA012768/AA/NIAAA NIH HHS/United States ; U01CD001645/CD/ODCDC CDC HHS/United States ; R01 DA021898/DA/NIDA NIH HHS/United States ; P30 DA027827/DA/NIDA NIH HHS/United States ; 2R01AA012768/AA/NIAAA NIH HHS/United States ; ... More +
R01 AA012768/AA/NIAAA NIH HHS/United States ; U01CD001645/CD/ODCDC CDC HHS/United States ; R01 DA021898/DA/NIDA NIH HHS/United States ; P30 DA027827/DA/NIDA NIH HHS/United States ; 2R01AA012768/AA/NIAAA NIH HHS/United States ; R01 MH062669/MH/NIMH NIH HHS/United States ; DA021898/DA/NIDA NIH HHS/United States ; 1P30DA027827/DA/NIDA NIH HHS/United States ; 3R01AA012768-09S1/AA/NIAAA NIH HHS/United States ; MH62669/MH/NIMH NIH HHS/United States ; MH48165/MH/NIMH NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b6a33b111454c4f1ff168938da242d17ff5783bd945fb2bddfc62346fec489b7
File Type:

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