The effect of neighborhood disadvantage, social ties, and genetic variation on the antisocial behavior of African American women: A multilevel analysis

Details

• Alternative Title:
  Dev Psychopathol
• Personal Author:
  LEI, MAN-KIT ; SIMONS, RONALD L. ; EDMOND, MARY BOND ; SIMONS, LESLIE GORDON ; CUTRONA, CAROLYN E.
• Description:
  Social disorganization theory posits that individuals who live in disadvantaged neighborhoods are more likely to engage in antisocial behavior than are those who live in advantaged neighborhoods and that neighborhood disadvantage asserts this effect through its disruptive impact on social ties. Past research on this framework has been limited in two respects. First, most studies have concentrated on adolescent males. In contrast, the present study focused on a sample of adult African American females. Second, past research has largely ignored individual-level factors that might explain why people who grow up in disadvantaged neighborhoods often do not engage in antisocial behavior. We investigated the extent to which genetic variation contributes to heterogeneity of response to neighborhood conditions. We found that the impact of neighborhood disadvantage on antisocial behavior was mediated by neighborhood social ties. Further, the analysis indicated that the effects of neighborhood disadvantage and social ties on antisocial behavior were moderated by genetic polymorphisms. Examination of these moderating effects provided support for the differential susceptibility model of Gene × Environment. The effect of Gene × Neighborhood Disadvantage on antisocial behavior was mediated by the effect of Gene × Neighborhood Social Ties, providing support for an expanded view of social disorganization theory.
• Subjects:
  Adolescent Adult Antisocial Personality Disorder Black Or African American Child Female Gene-Environment Interaction Genetic Variation Humans Interview, Psychological Longitudinal Studies Male Receptors, Dopamine D4 Residence Characteristics Serotonin Plasma Membrane Transport Proteins Social Support Vulnerable Populations Young Adult

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• Source:
  Dev Psychopathol. 26(4 0 1):1113-1128
• Pubmed ID:
  24713449
• Pubmed Central ID:
  PMC4527049
• Document Type:
  Journal Article
• Funding:
  R01 AA012768/AA/NIAAA NIH HHS/United States ; U01CD001645/CD/ODCDC CDC HHS/United States ; R01 DA021898/DA/NIDA NIH HHS/United States ; P30 DA027827/DA/NIDA NIH HHS/United States ; 2R01AA012768/AA/NIAAA NIH HHS/United States ; R01 MH062669/MH/NIMH NIH HHS/United States ; DA021898/DA/NIDA NIH HHS/United States ; 1P30DA027827/DA/NIDA NIH HHS/United States ; 3R01AA012768-09S1/AA/NIAAA NIH HHS/United States ; MH62669/MH/NIMH NIH HHS/United States ; MH48165/MH/NIMH NIH HHS/United States
• Volume:
  26
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b6a33b111454c4f1ff168938da242d17ff5783bd945fb2bddfc62346fec489b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/32706/cdc_32706_DS1.pdf
• File Type:
  [PDF - 661.17 KB ]