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Long-Distance Kissing Loop Interactions between a 3' Proximal Y-Shaped Structure and Apical Loops of 5' Hairpins Enhance Translation of Saguaro Cactus Virus
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8 15 2011
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Source: Virology. 2011; 417(1):113-125
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Alternative Title:Virology
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Description:Circularization of cellular mRNAs is a key event prior to translation initiation. We report that efficient translation of Saguaro cactus virus (SCV) requires a 3' translational enhancer (PTE) located partially in coding sequences. Unlike a similar PTE reported in the 3' UTR of Pea enation mosaic virus that does not engage in an RNA:RNA interaction (Wang Z. et al., J. Biol. Chem. 284, 14189-14202, 2009), the SCV PTE participates in long distance RNA:RNA interactions with hairpins located in the p26 ORF and in the 5' UTR of one subgenomic RNA. At least two additional RNA:RNA interactions are also present, one of which involves the p26 initiation codon. Similar PTE can be found in six additional carmoviruses that can putatively form long-distance interactions with 5' hairpins located in comparable positions.
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Pubmed ID:21664637
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Pubmed Central ID:PMC3152624
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Volume:417
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Issue:1
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