Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

Park, Sung Young; Choi, Dong Shin; Jin, Hye Jun; Park, Juhun; Byun, Kyung-Eun; Lee, Ki-Bum; Hong, Seunghun

doi:10.1021/nn2006128

Back to Previous Page

Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

Published Date:

May 13 2011

Publisher's site:

http://dx.doi.org/10.1021/nn2006128

Source:

ACS Nano. 5(6):4704-4711.

[PDF-1.91 MB]

Details:

Alternative Title:

ACS Nano

Personal Author:

Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; Park, Juhun ; Byun, Kyung-Eun ; ... More ▼

Description:

We report a method for selective growth and structural-polarization-controlled neuronal differentiation of human neural stem cells (hNSCs) into neurons using carbon nanotube network patterns. The CNT patterns provide synergistic cues for the differentiation of hNSCs in physiological solution and an optimal nanotopography at the same time with good biocompatibility. We demonstrated a polarization-controlled neuronal differentiation at the level of individual NSCs. This result should provide a stable and versatile platform for controlling the hNSC growth because CNT patterns are known to be stable in time unlike commonly used organic molecular patterns.

Subject:

[+]

Pubmed ID:

21568294

Pubmed Central ID:

PMC3125501

Document Type:

Journal Article

Funding:

1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; DP2 OD006462/OD/NIH HHS/United States ; DP2 OD006462-01/OD/NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

	nihms296807f4.gif	image/gif
	nihms296807f4.jpg	image/jpeg
	nihms296807f5.gif	image/gif
	nihms296807f5.jpg	image/jpeg
	NIHMS296807-supplement-1_si_001.pdf	application/pdf
	nihms296807.nxml	text/plain
	nihms296807f1.gif	image/gif
	nihms296807f1.jpg	image/jpeg
	nihms296807f2.gif	image/gif
	nihms296807f2.jpg	image/jpeg
	nihms296807f3.gif	image/gif
	nihms296807f3.jpg	image/jpeg

No Related Documents.

Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

[PDF - 578.07 KB]

Personal Author:

Solanki, Aniruddh ; Chueng, Sy-Tsong Dean ; ...

Published Date:

Jul 04 2013

Source:

Adv Mater. 2013; 25(38):5477-5482.

Description:

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating ...

File Type:

[PDF - 578.07 KB]

File Type:

[PDF - 578.07 KB]
Nanotechnology-Based Approaches for Guiding Neural Regeneration

[PDF - 1.16 MB]

Personal Author:

Shah, Shreyas ; Solanki, Aniruddh ; ...

Published Date:

Dec 14 2015

Source:

Acc Chem Res. 49(1):17-26.

Description:

The mammalian brain is a phenomenal piece of "organic machinery" that has fascinated scientists and clinicians for centuries. The intricate network of...

File Type:

[PDF - 1.16 MB]

File Type:

[PDF - 1.16 MB]
Guiding Stem Cell Differentiation into Oligodendrocytes Using Graphene-Nanofiber Scaffolds

[PDF - 2.62 MB]

Personal Author:

Shah, Shreyas ; Yin, Perry T. ; ...

Published Date:

Mar 26 2014

Source:

Adv Mater. 26(22):3673-3680.

File Type:

[PDF - 2.62 MB]

File Type:

[PDF - 2.62 MB]
Multimodal magnetic core-shell nanoparticles for effective stem cell differentiation and imaging**

[PDF - 1.47 MB]

Personal Author:

Shah, Birju ; Yin, Perry T. ; ...

Published Date:

May 06 2013

Source:

Angew Chem Int Ed Engl. 52(24):6190-6195.

File Type:

[PDF - 1.47 MB]

File Type:

[PDF - 1.47 MB]
TLX: A Master Regulator for Neural Stem Cell Maintenance and Neurogenesis

[PDF - 631.24 KB]

Personal Author:

Islam, Mohammed M. ; Zhang, Chun-Li ;

Published Date:

Jun 13 2014

Source:

Biochim Biophys Acta. 2014; 1849(2):210-216.

Description:

The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis....

File Type:

[PDF - 631.24 KB]

File Type:

[PDF - 631.24 KB]

Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

You May Also Like:

Have Questions?

CDC INFORMATION

CONNECT WITH CDC