Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

Park, Sung Young; Choi, Dong Shin; Jin, Hye Jun; Park, Juhun; Byun, Kyung-Eun; Lee, Ki-Bum; Hong, Seunghun

doi:10.1021/nn2006128

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Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

May 13 2011
By Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; ...
http://dx.doi.org/10.1021/nn2006128
Source: ACS Nano. 5(6):4704-4711.

[PDF-1.91 MB]

English

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Details:

Alternative Title:

ACS Nano
Personal Author:

Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; Park, Juhun ; Byun, Kyung-Eun ; ... More +

Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; Park, Juhun ; Byun, Kyung-Eun ; Lee, Ki-Bum ; Hong, Seunghun Less -
Description:

We report a method for selective growth and structural-polarization-controlled neuronal differentiation of human neural stem cells (hNSCs) into neurons using carbon nanotube network patterns. The CNT patterns provide synergistic cues for the differentiation of hNSCs in physiological solution and an optimal nanotopography at the same time with good biocompatibility. We demonstrated a polarization-controlled neuronal differentiation at the level of individual NSCs. This result should provide a stable and versatile platform for controlling the hNSC growth because CNT patterns are known to be stable in time unlike commonly used organic molecular patterns.
Subjects:

[+]

Adsorption Biocompatible Materials Cell Differentiation Cell Proliferation Cell Survival Epidermal Growth Factor Fibroblast Growth Factor 2 Humans Immunohistochemistry Microscopy, Electron, Scanning Nanotechnology Nanotubes, Carbon Neural Stem Cells Resins, Synthetic
Source:

ACS Nano. 5(6):4704-4711.
Pubmed ID:

21568294
Pubmed Central ID:

PMC3125501
Document Type:

Journal Article
Funding:

1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; DP2 OD006462/OD/NIH HHS/United States ; DP2 OD006462-01/OD/NIH HHS/United States

1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; DP2 OD006462/OD/NIH HHS/United States ; DP2 OD006462-01/OD/NIH HHS/United States Less -
Volume:

5
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:c7e84b2fec71e926c2a02e65ad51462bc2581be373148c1c82d509f52801f821
Download URL:

https://stacks.cdc.gov/view/cdc/33220/cdc_33220_DS1.pdf
File Type:

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