Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating
Published Date:May 13 2011
Source:ACS Nano. 5(6):4704-4711.
Epidermal Growth Factor
Fibroblast Growth Factor 2
Microscopy, Electron, Scanning
Neural Stem Cells
Pubmed Central ID:PMC3125501
Funding:1DP20D006462-01/DP/NCCDPHP CDC HHS/United States
DP2 OD006462/OD/NIH HHS/United States
DP2 OD006462-01/OD/NIH HHS/United States
Description:We report a method for selective growth and structural-polarization-controlled neuronal differentiation of human neural stem cells (hNSCs) into neurons using carbon nanotube network patterns. The CNT patterns provide synergistic cues for the differentiation of hNSCs in physiological solution and an optimal nanotopography at the same time with good biocompatibility. We demonstrated a polarization-controlled neuronal differentiation at the level of individual NSCs. This result should provide a stable and versatile platform for controlling the hNSC growth because CNT patterns are known to be stable in time unlike commonly used organic molecular patterns.
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