Details:

Alternative Title:
ACS Nano
Publisher's site:
http://dx.doi.org/10.1021/nn2006128
Personal Author:
Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; Park, Juhun ; Byun, Kyung-Eun ; ... More +
Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; Park, Juhun ; Byun, Kyung-Eun ; Lee, Ki-Bum ; Hong, Seunghun ; Less -
Description:
We report a method for selective growth and structural-polarization-controlled neuronal differentiation of human neural stem cells (hNSCs) into neurons using carbon nanotube network patterns. The CNT patterns provide synergistic cues for the differentiation of hNSCs in physiological solution and an optimal nanotopography at the same time with good biocompatibility. We demonstrated a polarization-controlled neuronal differentiation at the level of individual NSCs. This result should provide a stable and versatile platform for controlling the hNSC growth because CNT patterns are known to be stable in time unlike commonly used organic molecular patterns.
Subject:
[+]
Adsorption
Article
Biocompatible Materials
Carbon Nanotubes
Cell Differentiation
Cell Proliferation
Cell Survival
Epidermal Growth Factor
Fibroblast Growth Factor 2
Humans
Immunohistochemistry
Micropattern
Microscopy, Electron, Scanning
Nanotechnology
Nanotopography
Nanotubes, Carbon
Neural Stem Cells
Polarization
Resins, Synthetic

Source:
ACS Nano. 5(6):4704-4711.
Pubmed ID:
21568294
Pubmed Central ID:
PMC3125501
Document Type:
Journal Article ;
Funding:
1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; DP2 OD006462/OD/NIH HHS/United States ; DP2 OD006462-01/OD/NIH HHS/United States ;
1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; DP2 OD006462/OD/NIH HHS/United States ; DP2 OD006462-01/OD/NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c7e84b2fec71e926c2a02e65ad51462bc2581be373148c1c82d509f52801f821
File Type:

Supporting Files

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