Polarization-Controlled Differentiation of Human Neural Stem Cells Using Synergistic Cues from the Patterns of Carbon Nanotube Monolayer Coating

Details

• Alternative Title:
  ACS Nano
• Personal Author:
  Park, Sung Young ; Choi, Dong Shin ; Jin, Hye Jun ; Park, Juhun ; Byun, Kyung-Eun ; Lee, Ki-Bum ; Hong, Seunghun
• Description:
  We report a method for selective growth and structural-polarization-controlled neuronal differentiation of human neural stem cells (hNSCs) into neurons using carbon nanotube network patterns. The CNT patterns provide synergistic cues for the differentiation of hNSCs in physiological solution and an optimal nanotopography at the same time with good biocompatibility. We demonstrated a polarization-controlled neuronal differentiation at the level of individual NSCs. This result should provide a stable and versatile platform for controlling the hNSC growth because CNT patterns are known to be stable in time unlike commonly used organic molecular patterns.
• Subjects:
  Adsorption Biocompatible Materials Cell Differentiation Cell Proliferation Cell Survival Epidermal Growth Factor Fibroblast Growth Factor 2 Humans Immunohistochemistry Microscopy, Electron, Scanning Nanotechnology Nanotubes, Carbon Neural Stem Cells Resins, Synthetic

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• Source:
  ACS Nano. 5(6):4704-4711.
• Pubmed ID:
  21568294
• Pubmed Central ID:
  PMC3125501
• Document Type:
  Journal Article
• Funding:
  1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; DP2 OD006462/OD/NIH HHS/United States ; DP2 OD006462-01/OD/NIH HHS/United States
• Volume:
  5
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c7e84b2fec71e926c2a02e65ad51462bc2581be373148c1c82d509f52801f821
• Download URL:
  https://stacks.cdc.gov/view/cdc/33220/cdc_33220_DS1.pdf
• File Type:
  [PDF - 1.91 MB ]