Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

Details

• Alternative Title:
  Adv Mater
• Personal Author:
  Solanki, Aniruddh ; Chueng, Sy-Tsong Dean ; Yin, Perry T. ; Kappera, Rajesh ; Chhowalla, Manish ; Lee, Ki-Bum
• Description:
  Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
• Subjects:
  Axons Biocompatible Materials Cell Differentiation Cell Proliferation Graphite Humans Nanoparticles Neural Stem Cells Oxides Silicon Dioxide
• Source:
  Adv Mater. 2013; 25(38):5477-5482
• Pubmed ID:
  23824715
• Pubmed Central ID:
  PMC4189106
• Document Type:
  Journal Article
• Funding:
  T32 GM008339/GM/NIGMS NIH HHSUnited States/ ; 1DP20D006462-01/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  25
• Issue:
  38
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fedca8d62a9500da22e2aa28ab4750b6467eb1b993c9cbdd0346c8eb165833bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/30140/cdc_30140_DS1.pdf
• File Type:
  [PDF - 578.07 KB ]