Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

Solanki, Aniruddh; Chueng, Sy-Tsong Dean; Yin, Perry T.; Kappera, Rajesh; Chhowalla, Manish; Lee, Ki-Bum

doi:10.1002/adma.201302219

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Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

Published Date:

Jul 04 2013

Publisher's site:

http://dx.doi.org/10.1002/adma.201302219

Source:

Adv Mater. 2013; 25(38):5477-5482.

[PDF-578.07 KB]

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Alternative Title:

Adv Mater

Personal Author:

Solanki, Aniruddh ; Chueng, Sy-Tsong Dean ; Yin, Perry T. ; Kappera, Rajesh ; Chhowalla, Manish ; ... More ▼

Description:

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

Subject:

[+]

Document Type:

Journal Article

Funding:

1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; T32 GM008339/GM/NIGMS NIH HHS/United States ;

Collection(s):

CDC Public Access

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Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

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