CHROMIUM EFFECTS ON GLUCOSE TOLERANCE AND INSULIN SESITIVITY IN PERSONS AT RISK FOR DIABETES MELLITUS
Published Date:2011 Jan-Feb
Source:Endocr Pract. 2010; 17(1):16-25.
Pubmed Central ID:PMC3118091
Funding:F32 AT002667/AT/NCCIH NIH HHS/United States
F32 AT002667/AT/NCCIH NIH HHS/United States
F32 AT002667-03/AT/NCCIH NIH HHS/United States
L30 AT004887/AT/NCCIH NIH HHS/United States
L30 AT004887-02/AT/NCCIH NIH HHS/United States
R01 ES016893/ES/NIEHS NIH HHS/United States
R21 AT001332/AT/NCCIH NIH HHS/United States
R21 AT001332-01A1/AT/NCCIH NIH HHS/United States
R21 AT001332-02/AT/NCCIH NIH HHS/United States
R21 AT001332-02S1/AT/NCCIH NIH HHS/United States
R21 AT1332/AT/NCCIH NIH HHS/United States
U48 DP000053/DP/NCCDPHP CDC HHS/United States
UL1 RR024139/RR/NCRR NIH HHS/United States
To investigate the effects of daily chromium picolinate supplementation on serum measures of glucose tolerance and insulin sensitivity in patients at high risk for type 2 diabetes mellitus.
We conducted a randomized, double-blind, placebo-controlled, modified cross-over clinical trial with 6-month sequences of intervention and placebo followed by a 6-month postintervention assessment. Adult patients with impaired fasting glucose, impaired glucose tolerance, or metabolic syndrome were enrolled. Participants received 6-month sequences of chromium picolinate or placebo at 1 of 2 dosages (500 or 1000 mcg daily). Primary outcome measures were change in fasting plasma glucose, 2-hour plasma glucose during oral glucose tolerance testing, fasting and 2-hour insulin, and homeostasis model assessment of insulin resistance (HOMA-IR). Secondary outcomes included anthropometric measures, blood pressure, endothelial function, hemoglobin A1c, lipids, and urinary microalbumin.
Fifty-nine participants were enrolled. No changes were seen in glucose level, insulin level, or HOMA-IR (all, P>.05) after 6 months of chromium at either dosage level (500 mcg or 1000 mcg daily) when compared with placebo. None of the secondary outcomes improved with either chromium dosage compared with placebo (P>.05).
Chromium supplementation does not appear to ameliorate insulin resistance or impaired glucose metabolism in patients at risk for type 2 diabetes and thus is unlikely to attenuate diabetes risk.
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