Details:

Alternative Title:
Cancer Epidemiol Biomarkers Prev
Publisher's site:
http://dx.doi.org/10.1158/1055-9965.EPI-11-0038
Personal Author:
Clarke, Christina A. ; Glaser, Sally L. ; Gomez, Scarlett L. ; Wang, Sophia S. ; Keegan, Theresa H. ; ... More +
Clarke, Christina A. ; Glaser, Sally L. ; Gomez, Scarlett L. ; Wang, Sophia S. ; Keegan, Theresa H. ; Yang, Juan ; Chang, Ellen T. Less -
Description:
Background

Malignancies of the lymphoid cells, including non-Hodgkin lymphomas (NHLs), Hodgkin lymphoma (HL) and multiple myeloma (MM), occur at much lower rates in Asians than other racial/ethnic groups in the United States (US). It remains unclear whether these deficits are explained by genetic or environmental factors. To better understand environmental contributions, we examined incidence patterns of lymphoid malignancies among populations characterized by ethnicity, birthplace, and residential neighborhood socioeconomic status (SES) and ethnic enclave status.

Methods

We obtained data regarding all Asian patients diagnosed with lymphoid malignancies between 1988 and 2004 from the California Cancer Registry and neighborhood characteristics from US Census data.

Results

While incidence rates of most lymphoid malignancies were lower among Asian than white populations, only follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and nodular sclerosis (NS) HL rates were statistically significantly lower among foreign-born than US-born Asians, with incidence rate ratios ranging from 0.34 to 0.87. Rates of CLL/SLL and NS HL were also lower among Asian women living in ethnic enclaves or lower-SES neighborhoods than those living elsewhere. Conclusions: These observations support strong roles of environmental factors in the causation of FL, CLL/SLL, and NS HL.

Impact

Studying specific lymphoid malignancies in US Asians may provide valuable insight towards understanding their environmental causes.


Subject:
[+]
Acculturation
Adolescent
Adult
Aged
Asian Americans
Child
Child, Preschool
Ethnicity
Female
Humans
Incidence
Infant
Infant, Newborn
Lymphoma
Male
Middle Aged
Registries
Residence Characteristics
Social Class
Young Adult

Source:
Cancer Epidemiol Biomarkers Prev. 20(6):1064-1077.
Pubmed ID:
21493873
Pubmed Central ID:
PMC3111874
Document Type:
Journal Article
Funding:
1U58DP00807-01/DP/NCCDPHP CDC HHS/United States ; N01 PC035136-21-0-0/PC/NCI NIH HHS/United States ; R01-CA121052/CA/NCI NIH HHS/United States ; R01-ES015552/ES/NIEHS NIH HHS/United States
1U58DP00807-01/DP/NCCDPHP CDC HHS/United States ; N01 PC035136-21-0-0/PC/NCI NIH HHS/United States ; R01-CA121052/CA/NCI NIH HHS/United States ; R01-ES015552/ES/NIEHS NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ecc98afccc869348826f71a078bdbd0dcc448bf16dec9ee8ac7890b8c2810282
File Type:

Supporting Files

• 	NIHMS288200-supplement-1.docx	docx
  	nihms288200.nxml	txt

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