Lymphoid malignancies in US Asians: incidence rate differences by birthplace and acculturation

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Clarke, Christina A. ; Glaser, Sally L. ; Gomez, Scarlett L. ; Wang, Sophia S. ; Keegan, Theresa H. ; Yang, Juan ; Chang, Ellen T.
• Description:
  Background
  
  Malignancies of the lymphoid cells, including non-Hodgkin lymphomas (NHLs), Hodgkin lymphoma (HL) and multiple myeloma (MM), occur at much lower rates in Asians than other racial/ethnic groups in the United States (US). It remains unclear whether these deficits are explained by genetic or environmental factors. To better understand environmental contributions, we examined incidence patterns of lymphoid malignancies among populations characterized by ethnicity, birthplace, and residential neighborhood socioeconomic status (SES) and ethnic enclave status.
  
  Methods
  
  We obtained data regarding all Asian patients diagnosed with lymphoid malignancies between 1988 and 2004 from the California Cancer Registry and neighborhood characteristics from US Census data.
  
  Results
  
  While incidence rates of most lymphoid malignancies were lower among Asian than white populations, only follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and nodular sclerosis (NS) HL rates were statistically significantly lower among foreign-born than US-born Asians, with incidence rate ratios ranging from 0.34 to 0.87. Rates of CLL/SLL and NS HL were also lower among Asian women living in ethnic enclaves or lower-SES neighborhoods than those living elsewhere. Conclusions: These observations support strong roles of environmental factors in the causation of FL, CLL/SLL, and NS HL.
  
  Impact
  
  Studying specific lymphoid malignancies in US Asians may provide valuable insight towards understanding their environmental causes.
  
  
• Subjects:
  Acculturation Adolescent Adult Aged Asian Child Child, Preschool Ethnicity Female Humans Incidence Infant Infant, Newborn Lymphoma Male Middle Aged Registries Residence Characteristics Social Class Young Adult

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 20(6):1064-1077.
• Pubmed ID:
  21493873
• Pubmed Central ID:
  PMC3111874
• Document Type:
  Journal Article
• Funding:
  1U58DP00807-01/DP/NCCDPHP CDC HHS/United States ; N01 PC035136-21-0-0/PC/NCI NIH HHS/United States ; R01-CA121052/CA/NCI NIH HHS/United States ; R01-ES015552/ES/NIEHS NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  20
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ecc98afccc869348826f71a078bdbd0dcc448bf16dec9ee8ac7890b8c2810282
• Download URL:
  https://stacks.cdc.gov/view/cdc/33208/cdc_33208_DS1.pdf
• File Type:
  [PDF - 97.49 KB ]