Details:

Alternative Title:
J Occup Environ Med
Publisher's site:
http://dx.doi.org/10.1097/JOM.0b013e31821854da
Personal Author:
Laohaudomchok, Wisanti ; Lin, Xihong ; Herrick, Robert F. ; Fang, Shona C. ; Cavallari, Jennifer M. ; ... More +
Laohaudomchok, Wisanti ; Lin, Xihong ; Herrick, Robert F. ; Fang, Shona C. ; Cavallari, Jennifer M. ; Christiani, David C. ; Weisskopf, Marc G. ; Less -
Description:
Objective This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers. Methods Air measurement data and work histories were used to determine manganese exposure over a workshift and cumulative exposure. Toenail samples (n=49), as well as blood and urine before (n=27) and after (urine, n=26; blood, n=24) a workshift were collected. Results Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in months 7-9, 10-12, and 7-12 before toenail clipping date, but not months 1-6. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese. Conclusions Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical workshift.
Subject:
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Adult
Article
Biological Markers
Biomarkers
Blood Manganese
Humans
Low-level Manganese Exposure
Manganese
Middle Aged
Nails
Occupational Exposure
Toenail Manganese
Urine Manganese
Welders
Welding Fumes

Source:
J Occup Environ Med. 53(5):506-510. ;
Pubmed ID:
21494156
Pubmed Central ID:
PMC3092003
Document Type:
Journal Article ;
Funding:
ES009860/ES/NIEHS NIH HHS/United States ; OH009762/OH/NIOSH CDC HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860-09/ES/NIEHS NIH HHS/United States ; T42OH008416-02/OH/NIOSH CDC HHS/United States ; ... More +
ES009860/ES/NIEHS NIH HHS/United States ; OH009762/OH/NIOSH CDC HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860-09/ES/NIEHS NIH HHS/United States ; T42OH008416-02/OH/NIOSH CDC HHS/United States ; T42OH008416-04/OH/NIOSH CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bb799a32aa4443bf2be904e5ec776c9eed881d3ae069f4a18491bd3f6177b469
File Type:

Supporting Files

• nihms-285799.nxml

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