Toenail, Blood and Urine as Biomarkers of Manganese Exposure
Published Date:May 2011
Source:J Occup Environ Med. 53(5):506-510.
Pubmed Central ID:PMC3092003
Funding:ES009860/ES/NIEHS NIH HHS/United States
OH009762/OH/NIOSH CDC HHS/United States
R01 ES009860/ES/NIEHS NIH HHS/United States
R01 ES009860-09/ES/NIEHS NIH HHS/United States
T42OH008416-02/OH/NIOSH CDC HHS/United States
T42OH008416-04/OH/NIOSH CDC HHS/United States
This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers.
Air measurement data and work histories were used to determine manganese exposure over a workshift and cumulative exposure. Toenail samples (n=49), as well as blood and urine before (n=27) and after (urine, n=26; blood, n=24) a workshift were collected.
Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in months 7-9, 10-12, and 7-12 before toenail clipping date, but not months 1-6. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese.
Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical workshift.
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