Toenail, Blood and Urine as Biomarkers of Manganese Exposure

Laohaudomchok, Wisanti; Lin, Xihong; Herrick, Robert F.; Fang, Shona C.; Cavallari, Jennifer M.; Christiani, David C.; Weisskopf, Marc G.

doi:10.1097/JOM.0b013e31821854da

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Toenail, Blood and Urine as Biomarkers of Manganese Exposure

Published Date:

May 2011

Publisher's site:

http://dx.doi.org/10.1097/JOM.0b013e31821854da New Site Icon

Source:

J Occup Environ Med. 53(5):506-510.

[PDF-382.27 KB]

Details:

Personal Authors:

Laohaudomchok, Wisanti ; Lin, Xihong ; Herrick, Robert F. ; Fang, Shona C. ; Cavallari, Jennifer M. ; ... More ▼

Keywords:

[+]

Pubmed ID:

21494156

Pubmed Central ID:

PMC3092003

Description:

Objective

This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers.

Methods

Air measurement data and work histories were used to determine manganese exposure over a workshift and cumulative exposure. Toenail samples (n=49), as well as blood and urine before (n=27) and after (urine, n=26; blood, n=24) a workshift were collected.

Results

Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in months 7-9, 10-12, and 7-12 before toenail clipping date, but not months 1-6. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese.

Conclusions

Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical workshift.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

ES009860/ES/NIEHS NIH HHS/United States
OH009762/OH/NIOSH CDC HHS/United States
R01 ES009860/ES/NIEHS NIH HHS/United States
R01 ES009860-09/ES/NIEHS NIH HHS/United States
T42OH008416-02/OH/NIOSH CDC HHS/United States
T42OH008416-04/OH/NIOSH CDC HHS/United States

Supporting Files:

nihms-285799.nxml

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