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Toenail, Blood and Urine as Biomarkers of Manganese Exposure
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May 2011
Source: J Occup Environ Med. 53(5):506-510. -
Alternative Title:J Occup Environ Med
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Description:Objective
This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers.
Methods
Air measurement data and work histories were used to determine manganese exposure over a workshift and cumulative exposure. Toenail samples (n=49), as well as blood and urine before (n=27) and after (urine, n=26; blood, n=24) a workshift were collected.
Results
Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in months 7-9, 10-12, and 7-12 before toenail clipping date, but not months 1-6. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese.
Conclusions
Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical workshift.
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Subject:
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Pubmed ID:21494156
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Pubmed Central ID:PMC3092003
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