Toenail, Blood and Urine as Biomarkers of Manganese Exposure

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Laohaudomchok, Wisanti ; Lin, Xihong ; Herrick, Robert F. ; Fang, Shona C. ; Cavallari, Jennifer M. ; Christiani, David C. ; Weisskopf, Marc G.
• Description:
  Objective
  
  This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers.
  
  Methods
  
  Air measurement data and work histories were used to determine manganese exposure over a workshift and cumulative exposure. Toenail samples (n=49), as well as blood and urine before (n=27) and after (urine, n=26; blood, n=24) a workshift were collected.
  
  Results
  
  Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in months 7-9, 10-12, and 7-12 before toenail clipping date, but not months 1-6. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese.
  
  Conclusions
  
  Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical workshift.
  
  
• Subjects:
  Adult Biological Markers Humans Middle Aged Nails Occupational Exposure
• Source:
  J Occup Environ Med. 53(5):506-510.
• Pubmed ID:
  21494156
• Pubmed Central ID:
  PMC3092003
• Document Type:
  Journal Article
• Funding:
  ES009860/ES/NIEHS NIH HHS/United States ; OH009762/OH/NIOSH CDC HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860-09/ES/NIEHS NIH HHS/United States ; T42OH008416-02/OH/NIOSH CDC HHS/United States ; T42OH008416-04/OH/NIOSH CDC HHS/United States
• Volume:
  53
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bb799a32aa4443bf2be904e5ec776c9eed881d3ae069f4a18491bd3f6177b469
• Download URL:
  https://stacks.cdc.gov/view/cdc/33200/cdc_33200_DS1.pdf
• File Type:
  [PDF - 382.27 KB ]