The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis

Hüttemann, Maik; Pecina, Petr; Rainbolt, Matthew; Sanderson, Thomas H.; Kagan, Valerian E.; Samavati, Lobelia; Doan, Jeffrey W.; Lee, Icksoo

doi:10.1016/j.mito.2011.01.010

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The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis

Published Date:

Feb 04 2011

Publisher's site:

http://dx.doi.org/10.1016/j.mito.2011.01.010 New Site Icon

Source:

Mitochondrion. 2010; 11(3):369-381.

[PDF-722.64 KB]

Details:

Personal Authors:

Hüttemann, Maik ; Pecina, Petr ; Rainbolt, Matthew ; Sanderson, Thomas H. ; Kagan, Valerian E. ; ... More ▼

Keywords:

[+]

Pubmed ID:

21296189

Pubmed Central ID:

PMC3075374

Description:

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy conditions, produces ROS with the co-factor p66(Shc), and oxidizes cardiolipin during apoptosis. The recent finding that Cytc is phosphorylated in vivo underpins a model for the pivotal role of Cytc regulation in making life and death decisions. An apoptotic sequence of events is proposed involving changes in Cytc phosphorylation, increased ROS via increased mitochondrial membrane potentials or the p66(Shc) pathway, and oxidation of cardiolipin by Cytc followed by its release from the mitochondria. Cytc regulation in respiration and cell death is discussed in a human disease context including neurodegenerative and cardiovascular diseases, cancer, and sepsis.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

GM089900/GM/NIGMS NIH HHS/United States
HL094488/HL/NHLBI NIH HHS/United States
HL70755/HL/NHLBI NIH HHS/United States
OH008282/OH/NIOSH CDC HHS/United States
R01 GM089900/GM/NIGMS NIH HHS/United States
R01 GM089900-01A1/GM/NIGMS NIH HHS/United States
U19A1068021/PHS HHS/United States

Supporting Files:

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