The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis

Hüttemann, Maik; Pecina, Petr; Rainbolt, Matthew; Sanderson, Thomas H.; Kagan, Valerian E.; Samavati, Lobelia; Doan, Jeffrey W.; Lee, Icksoo

doi:10.1016/j.mito.2011.01.010

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis

Published Date:

Feb 04 2011

Publisher's site:

http://dx.doi.org/10.1016/j.mito.2011.01.010 New Site Icon

Source:

Mitochondrion. 2010; 11(3):369-381.

[PDF-722.64 KB]

Details:

Personal Authors:

Hüttemann, Maik ; Pecina, Petr ; Rainbolt, Matthew ; Sanderson, Thomas H. ; Kagan, Valerian E. ; ... More ▼

Keywords:

[+]

Pubmed ID:

21296189

Pubmed Central ID:

PMC3075374

Description:

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy conditions, produces ROS with the co-factor p66(Shc), and oxidizes cardiolipin during apoptosis. The recent finding that Cytc is phosphorylated in vivo underpins a model for the pivotal role of Cytc regulation in making life and death decisions. An apoptotic sequence of events is proposed involving changes in Cytc phosphorylation, increased ROS via increased mitochondrial membrane potentials or the p66(Shc) pathway, and oxidation of cardiolipin by Cytc followed by its release from the mitochondria. Cytc regulation in respiration and cell death is discussed in a human disease context including neurodegenerative and cardiovascular diseases, cancer, and sepsis.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

GM089900/GM/NIGMS NIH HHS/United States
HL094488/HL/NHLBI NIH HHS/United States
HL70755/HL/NHLBI NIH HHS/United States
OH008282/OH/NIOSH CDC HHS/United States
R01 GM089900/GM/NIGMS NIH HHS/United States
R01 GM089900-01A1/GM/NIGMS NIH HHS/United States
U19A1068021/PHS HHS/United States

Supporting Files:

	nihms-272788.nxml	application/octet-stream
	nihms-272788-f0001.gif	image/gif
	nihms-272788-f0001.jpg	image/jpeg
	nihms-272788-f0002.gif	image/gif
	nihms-272788-f0002.jpg	image/jpeg
	nihms-272788-f0003.gif	image/gif
	nihms-272788-f0003.jpg	image/jpeg
	nihms-272788-f0004.gif	image/gif
	nihms-272788-f0004.jpg	image/jpeg

No Related Documents.

You May Also Like:

Cardiolipin asymmetry, oxidation and signaling

Personal Author:

Kagan, Valerian E.; Chu, Charleen T.; Tyurina, Yulia Y.; Cheikhi, Amin; Bayir, Hülya;

Published:

Dec 01 2013

Source:

Chem Phys Lipids. 2013; 179:64-69.

Description:

Cardiolipins (CLs) are ancient and unusual dimeric phospholipids localized in the plasma membrane of bacteria and in the inner mitochondrial membrane of eukaryotes. In mitochondria, two types of asymmetries--trans-membrane and molecular--are essentia...

File Type:

[PDF - 946.07 KB]
Known Unknowns of Cardiolipin Signaling: The Best Is Yet To Come

Personal Author:

Maguire, John J.; Tyurina, Yulia Y.; Mohammadyani, Dariush; Kapralov, Aleksandr A.; Anthonymuthu, Tamil S.; Qu, Feng; Amoscato, Andrew A.; Sparvero, Louis J.; Tyurin, Vladimir A.; Planas-Iglesias, Joan; He, Rong-Rong; Klein-Seetharaman, Judith; Bayır, Hülya; Kagan, Valerian E.;

Published:

Aug 04 2016

Source:

Biochim Biophys Acta. 1862(1):8-24.

Description:

Since its discovery 75years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surg...

File Type:

[PDF - 3.33 MB]
Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids

Personal Author:

Kagan, Valerian E.; Bayir, Hülya; Tyurina, Yulia Y.; Bolevich, Sergey B.; Maguire, John J.; Fadeel, Bengt; Balasubramanian, Krishnakumar;

Published:

Feb 03 2017

Source:

Biochem Biophys Res Commun. 482(3):482-490.

Description:

High fidelity of biological systems is frequently achieved by duplication of the essential intracellular machineries or, removal of the entire cell, which becomes unnecessary or even harmful in altered physiological environments. Carefully controlled...

File Type:

[PDF - 554.42 KB]
Enzymatic Oxidative Biodegradation of Nanoparticles: Mechanisms, Significance and Applications

Personal Author:

Vlasova, Irina I.; Kapralov, Alexandr A.; Michael, Zachary P.; Burkert, Seth C.; Shurin, Michael R.; Star, Alexander; Shvedova, Anna A.; Kagan, Valerian E.;

Published:

Jan 06 2016

Source:

Toxicol Appl Pharmacol. 299:58-69.

Description:

Biopersistence of carbon nanotubes, graphene oxide (GO) and several other types of carbonaceous nanomaterials is an essential determinant of their health effects. Successful biodegradation is one of the major factors defining the life span and biolog...

File Type:

[PDF - 2.36 MB]
mitochondrial pathway for biosynthesis of lipid mediators

Personal Author:

Tyurina, Yulia Y.; Poloyac, Samuel M.; Tyurin, Vladimir A.; Kapralov, Alexander A.; Jiang, Jianfei; Anthonymuthu, Tamil Selvan; Kapralova, Valentina I.; Vikulina, Anna S.; Jung, Mi-Yeon; Epperly, Michael W.; Mohammadyani, Dariush; Klein-Seetharaman, Judith; Jackson, Travis C.; Kochanek, Patrick M.; Pitt, Bruce R.; Greenberger, Joel S.; Vladimirov, Yury A.; Bayır, Hülya; Kagan, Valerian E.;

Published:

Apr 20 2014

Source:

Nat Chem. 6(6):542-552.

Description:

The central role of mitochondria in metabolic pathways and in cell-death mechanisms requires sophisticated signalling systems. Essential in this signalling process is an array of lipid mediators derived from polyunsaturated fatty acids. However, the ...

File Type:

[PDF - 2.50 MB]