Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates

Millman, Alexander J.; Reed, Carrie; Kirley, Pam Daily; Aragon, Deborah; Meek, James; Farley, Monica M.; Ryan, Patricia; Collins, Jim; Lynfield, Ruth; Baumbach, Joan; Zansky, Shelley; Bennett, Nancy M.; Fowler, Brian; Thomas, Ann; Lindegren, Mary L.; Atkinson, Annette; Finelli, Lyn; Chaves, Sandra S.

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Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates

Supporting Files

Sep 2015
By Millman, Alexander J. ; Reed, Carrie ; Kirley, Pam Daily ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Millman, Alexander J. ; Reed, Carrie ; Kirley, Pam Daily ; Aragon, Deborah ; Meek, James ; Farley, Monica M. ; Ryan, Patricia ; Collins, Jim ; Lynfield, Ruth ; Baumbach, Joan ; Zansky, Shelley ; Bennett, Nancy M. ; Fowler, Brian ; Thomas, Ann ; Lindegren, Mary L. ; Atkinson, Annette ; Finelli, Lyn ; Chaves, Sandra S.
Description:

Diagnostic test sensitivity affects rate estimates for laboratory-confirmed influenza-associated hospitalizations. We used data from FluSurv-NET, a national population-based surveillance system for laboratory-confirmed influenza hospitalizations, to capture diagnostic test type by patient age and influenza season. We calculated observed rates by age group and adjusted rates by test sensitivity. Test sensitivity was lowest in adults >65 years of age. For all ages, reverse transcription PCR was the most sensitive test, and use increased from <10% during 2003-2008 to ≈70% during 2009-2013. Observed hospitalization rates per 100,000 persons varied by season: 7.3-50.5 for children <18 years of age, 3.0-30.3 for adults 18-64 years, and 13.6-181.8 for adults >65 years. After 2009, hospitalization rates adjusted by test sensitivity were ≈15% higher for children <18 years, ≈20% higher for adults 18-64 years, and ≈55% for adults >65 years of age. Test sensitivity adjustments improve the accuracy of hospitalization rate estimates.
Subjects:

Communicable Disease Control Communicable Diseases, Emerging Community Networks Humans Influenza, Human Patient Admission Population Surveillance Process Assessment (Health Care)
Source:

Emerg Infect Dis. 21(9):1595-1601
Pubmed ID:

26292017
Pubmed Central ID:

PMC4550134
Document Type:

Journal Article
Funding:

U38 HM000414/HM/NCHM CDC HHS/United States ; 5U38HM000414/HM/NCHM CDC HHS/United States ; RFA-CK12-1202/CK/NCEZID CDC HHS/United States
Place as Subject:

United States
Location:

North America
Volume:

21
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7da9f226e9658e2c17929a9afbfe655696b2f53e5b7dff365e810d1bbeaac360
Download URL:

https://stacks.cdc.gov/view/cdc/33139/cdc_33139_DS1.pdf
File Type:

[PDF - 1.50 MB ]

File Language:

English

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