Welcome to CDC Stacks | Blood α-Synuclein in Agricultural Pesticide Handlers in Central Washington State - 33046 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Blood α-Synuclein in Agricultural Pesticide Handlers in Central Washington State
Filetype[PDF - 541.40 KB]


Details:
  • Pubmed ID:
    25460623
  • Pubmed Central ID:
    PMC4548290
  • Funding:
    ES016873/ES/NIEHS NIH HHS/United States
    ES019277/ES/NIEHS NIH HHS/United States
    P30 ES007033/ES/NIEHS NIH HHS/United States
    P30ES007033/ES/NIEHS NIH HHS/United States
    P42 ES004696/ES/NIEHS NIH HHS/United States
    R01 ES016873/ES/NIEHS NIH HHS/United States
    R01 ES019277/ES/NIEHS NIH HHS/United States
    T32 ES015459/ES/NIEHS NIH HHS/United States
    U01 NS082137/NS/NINDS NIH HHS/United States
    U01NS082137/NS/NINDS NIH HHS/United States
    U54 HD083091/HD/NICHD NIH HHS/United States
    U54 OH007544/OH/NIOSH CDC HHS/United States
    U54OH007544/OH/NIOSH CDC HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Epidemiologic studies suggest that occupational exposure to pesticides might increase Parkinson disease risk. Some pesticides, such as the organophosphorus insecticide chlorpyrifos, appear to increase the expression of α-synuclein, a protein critically involved in Parkinson disease. Therefore, we assessed total blood cell α-synuclein in 90 specimens from 63 agricultural pesticide handlers, mainly Hispanic men from central Washington State, who participated in the state's cholinesterase monitoring program in 2007-2010. Additionally, in age-adjusted linear regression models for repeated measures, we assessed whether α-synuclein levels were associated with butyrylcholinesterase-chlorpyrifos adducts or cholinesterase inhibition measured in peripheral blood, or with self-reported pesticide exposure or paraoxonase (PON1) genotype. There was no evidence by any of those indicators that exposure to chlorpyrifos was associated with greater blood α-synuclein. We observed somewhat greater α-synuclein with the PON1-108T (lower paraoxonase enzyme) allele, and with ≥ 10 h of exposure to cholinesterase inhibiting insecticides in the preceding 30 days, but neither of these associations followed a clear dose-response pattern. These results suggest that selected genetic and environmental factors may affect α-synuclein blood levels. However, longitudinal studies with larger numbers of pesticide handlers will be required to confirm and elucidate the possible associations observed in this exploratory cross-sectional study.