Blood α-Synuclein in Agricultural Pesticide Handlers in Central Washington State

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Nielsen, Susan Searles ; Checkoway, Harvey ; Zhang, Jing ; Hofmann, Jonathan N. ; Keifer, Matthew C. ; Paulsen, Michael ; Farin, Federico M. ; Cook, Travis J. ; Simpson, Christopher D.
• Description:
  Epidemiologic studies suggest that occupational exposure to pesticides might increase Parkinson disease risk. Some pesticides, such as the organophosphorus insecticide chlorpyrifos, appear to increase the expression of α-synuclein, a protein critically involved in Parkinson disease. Therefore, we assessed total blood cell α-synuclein in 90 specimens from 63 agricultural pesticide handlers, mainly Hispanic men from central Washington State, who participated in the state's cholinesterase monitoring program in 2007-2010. Additionally, in age-adjusted linear regression models for repeated measures, we assessed whether α-synuclein levels were associated with butyrylcholinesterase-chlorpyrifos adducts or cholinesterase inhibition measured in peripheral blood, or with self-reported pesticide exposure or paraoxonase (PON1) genotype. There was no evidence by any of those indicators that exposure to chlorpyrifos was associated with greater blood α-synuclein. We observed somewhat greater α-synuclein with the PON1-108T (lower paraoxonase enzyme) allele, and with ≥ 10 h of exposure to cholinesterase inhibiting insecticides in the preceding 30 days, but neither of these associations followed a clear dose-response pattern. These results suggest that selected genetic and environmental factors may affect α-synuclein blood levels. However, longitudinal studies with larger numbers of pesticide handlers will be required to confirm and elucidate the possible associations observed in this exploratory cross-sectional study.
• Subjects:
  Agriculture Alpha-Synuclein Article Aryldialkylphosphatase Chlorpyrifos Humans Male Occupational Exposure Parkinson Disease Pesticides Washington α-Synuclein

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• Source:
  Environ Res. 136:75-81.
• Pubmed ID:
  25460623
• Pubmed Central ID:
  PMC4548290
• Document Type:
  Journal Article
• Funding:
  ES016873/ES/NIEHS NIH HHS/United States ; ES019277/ES/NIEHS NIH HHS/United States ; P30 ES007033/ES/NIEHS NIH HHS/United States ; P30ES007033/ES/NIEHS NIH HHS/United States ; P42 ES004696/ES/NIEHS NIH HHS/United States ; R01 ES016873/ES/NIEHS NIH HHS/United States ; R01 ES019277/ES/NIEHS NIH HHS/United States ; T32 ES015459/ES/NIEHS NIH HHS/United States ; U01 NS082137/NS/NINDS NIH HHS/United States ; U01NS082137/NS/NINDS NIH HHS/United States ; U54 HD083091/HD/NICHD NIH HHS/United States ; U54 OH007544/OH/NIOSH CDC HHS/United States ; U54OH007544/OH/NIOSH CDC HHS/United States
• Volume:
  136
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ddc4158cced55907ff1ef821052a66f3b27eabce1ad1c9b9022f7253ea8e95aa
• Download URL:
  https://stacks.cdc.gov/view/cdc/33046/cdc_33046_DS1.pdf
• File Type:
  [PDF - 541.40 KB ]