Blood alpha-synuclein in agricultural pesticide handlers in central Washington State

Details

• Personal Author:
  Checkoway, Harvey ; Cook TJ ; Farin FM ; Hofmann JN ; Keifer MC ; Paulsen M ; Searles Nielsen S ; Simpson CD ; Zhang J
• Description:
  Epidemiologic studies suggest that occupational exposure to pesticides might increase Parkinson disease risk. Some pesticides, such as the organophosphorus insecticide chlorpyrifos, appear to increase the expression of a-synuclein, a protein critically involved in Parkinson disease. Therefore, we assessed total blood cell a-synuclein in 90 specimens from 63 agricultural pesticide handlers, mainly Hispanic men from central Washington State, who participated in the state's cholinesterase monitoring program in 2007-2010. Additionally, in age-adjusted linear regression models for repeated measures, we assessed whether a-synuclein levels were associated with butyrylcholinesterase-chlorpyrifos adducts or cholinesterase inhibition measured in peripheral blood, or with self-reported pesticide exposure or paraoxonase (PON1) genotype. There was no evidence by any of those indicators that exposure to chlorpyrifos was associated with greater blood a-synuclein. We observed somewhat greater a-synuclein with the PON1-108T (lower paraoxonase enzyme) allele, and with = 10 h of exposure to cholinesterase inhibiting insecticides in the preceding 30 days, but neither of these associations followed a clear dose-response pattern. These results suggest that selected genetic and environmental factors may affect a-synuclein blood levels. However, longitudinal studies with larger numbers of pesticide handlers will be required to confirm and elucidate the possible associations observed in this exploratory cross-sectional study. [Description provided by NIOSH]
• Subjects:
  Blood Epidemiology Hematologic Tests Insecticides Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Aryldialkylphosphatase Author Keywords: Alpha-Synuclein Blood-cells Blood-samples Blood-sampling Chlorpyrifos Exposure-limits Organophosphorus-pesticides Parkinson Disease Pesticides Pesticides-and-agricultural-chemicals Proteins Risk-factors

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-81
• Volume:
  136
• NIOSHTIC Number:
  nn:20045738
• Citation:
  Environ Res 2015 Jan; 136:75-81
• Contact Point Address:
  Susan Searles Nielsen, University of Washington, Department of Neurology, Box 359775, Seattle, WA 98195-9775
• Email:
  ssn@uw.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Environmental Research
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:55c0791bcaf940b50587072f43fdbc6c99e2352485be1b939218b889f9623e73b0c6364b320a965b9c3a671027d87b98f8422baeab5e4eb9e91c607b40763ba4
• Download URL:
  https://stacks.cdc.gov/view/cdc/201039/cdc_201039_DS1.pdf
• File Type:
  [PDF - 331.94 KB ]