Predominance of HIV-1 subtype A and D infections in Uganda.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hu, D. J. ; Baggs, J. ; Downing, R. G. ; Pieniazek, D. ; Dorn, J. ; Fridlund, C. ; Biryahwaho, B. ; Sempala, S. D. ; Rayfield, M. A. ; Dondero, T. J. ; Lal, R.
• Description:
  To better characterize the virus isolates associated with the HIV-1 epidemic in Uganda, 100 specimens from HIV-1-infected persons were randomly selected from each of two periods from late 1994 to late 1997. The 200 specimens were classified into HIV-1 subtypes by sequence- based phylogenetic analysis of the envelope (env) gp41 region; 98 (49%) were classified as env subtype A, 96 (48%) as D, 5 (2.5%) as C, and 1 was not classified as a known env subtype. Demographic characteristics of persons infected with the two principal HIV-1 subtypes, A and D, were very similar, and the proportion of either subtype did not differ significantly between early and later periods. Our systematic characterization of the HIV-1 epidemic in Uganda over an almost 3-year period documented that the distribution and degree of genetic diversity of the HIV subtypes A and D are very similar and did not change appreciably over that time.
• Subjects:
  Acquired Immunodeficiency Syndrome Adult Female Hiv-1 Humans Male Phylogeny
• Source:
  Emerg Infect Dis. 6(6):609-615.
• Document Type:
  Journal Article
• Place as Subject:
  Uganda
• Location:
  Africa
• Volume:
  6
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b0670ac10584cc478c100932a021bd2a60b6898ee9435c2e0a91cac5dd11a6de
• Download URL:
  https://stacks.cdc.gov/view/cdc/3300/cdc_3300_DS1.pdf
• File Type:
  [PDF - 75.92 KB ]