Details:

Alternative Title:
Dis Markers
Publisher's site:
http://dx.doi.org/10.1155/2015/282145
Personal Author:
Taioli, Emanuela ; Wolf, Andrea S. ; Moline, Jacqueline M. ; Camacho-Rivera, Marlene ; Flores, Raja M.
Taioli, Emanuela ; Wolf, Andrea S. ; Moline, Jacqueline M. ; Camacho-Rivera, Marlene ; Flores, Raja M. Less -
Description:
Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival.|All cases of pathologically proven MPM were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed according to self-reported race (black or white).|There were 13,046 white and 688 black MPM patients (incidence: 1.1 per 100,000 whites; 0.5 per 100,000 blacks; age-adjusted, p = 0.01). Black patients were more likely to be female, younger, and with advanced stage and less likely to undergo cancer-directed surgery than whites, after adjustment by stage. On multivariable analysis, younger age and having surgery were associated with longer survival for both cohorts; female gender (HR 0.82 (0.77-0.88)) and early stage at diagnosis (HR 0.83 (0.76-0.90)) were predictive of longer survival in white, but not in black, patients.|Surgery was associated with improved survival for both black and white MPM patients. However, black patients were less likely to undergo cancer-directed surgery. Increased surgical intervention in MPM black patients with early stage disease may improve their survival.
Subject:
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Research Article

Source:
Dis Markers. 2015; 2015.
Pubmed ID:
26063951
Pubmed Central ID:
PMC4430630
Document Type:
Journal Article
Funding:
5R01TS000099-05/TS/ATSDR CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2932b2ad2adc3017d838ff4e56d51d84b2c96b17665195b8668fc8465104e60f
File Type:

Supporting Files

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  	DM2015-282145.nxml	txt
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