Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust

Details

• Alternative Title:
  Transl Res
• Personal Author:
  Nordgren, Tara M. ; Bauer, Christopher D. ; Heires, Art J. ; Poole, Jill A. ; Wyatt, Todd A. ; West, William W. ; Romberger, Debra J.
• Description:
  Agriculture industry workers are at a higher risk for chronic bronchitis and obstructive pulmonary diseases, and current therapeutics are not entirely effective. We previously found that the specialized proresolving lipid mediator maresin-1 (MaR1) reduced proinflammatory cytokine release and intracellular adhesion molecule-1 (ICAM-1) expression in bronchial epithelial cells exposed to extracts of organic dust (DE) derived from swine confinement facilities in vitro. The objective of this study was to determine whether MaR1 is effective at limiting lung inflammation associated with acute and repetitive exposures to DE in an established murine model of inhalant dust exposures. C57Bl/6 mice were treated with MaR1 or vehicle control and intranasally instilled with DE once or daily for 3 weeks. Bronchioalveolar lavage fluid was analyzed for total and differential cell counts and proinflammatory cytokine levels, and lung tissues were assessed for histopathology and ICAM-1 expression. In both single and repetitive DE exposure studies, MaR1 significantly decreased bronchoalveolar lavage neutrophil infiltration, interleukin 6, tumor necrosis factor α, and chemokine C-X-C motif ligand 1 levels without altering repetitive DE-induced bronchioalveolar inflammation or lymphoid aggregate formation. Lung tissue ICAM-1 expression was also reduced in both single and repetitive exposure studies. These data suggest that MaR1 might contribute to an effective strategy to reduce airway inflammatory diseases induced by agricultural-related organic dust environmental exposures.
• Subjects:
  Agricultural Workers' Diseases Air Pollutants, Occupational Animal Husbandry Animals Bronchoalveolar Lavage Fluid Cytokines Disease Models, Animal Docosahexaenoic Acids Dust Humans Intercellular Adhesion Molecule-1 Male Mice Mice, Inbred C57BL Neutrophil Infiltration Organic Chemicals Particulate Matter Pneumonia Sus Scrofa Translational Research, Biomedical

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• Source:
  Transl Res. 2015; 166(1):57-69
• Pubmed ID:
  25655838
• Pubmed Central ID:
  PMC4458456
• Document Type:
  Journal Article
• Funding:
  F32 ES022913/ES/NIEHS NIH HHSUnited States/ ; R010H008539/PHS HHSUnited States/ ; R01 OH008539/OH/NIOSH CDC HHSUnited States/ ; R01OH010162/OH/NIOSH CDC HHSUnited States/ ; R01ES0193525/ES/NIEHS NIH HHSUnited States/ ; R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54OH010162/OH/NIOSH CDC HHSUnited States/ ; F32ES022913/ES/NIEHS NIH HHSUnited States/
• Volume:
  166
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d84dff4415fe2a975369dc7846dcff94e7ec7b376fbcb5c6eab0e00e9a24b890
• Download URL:
  https://stacks.cdc.gov/view/cdc/32584/cdc_32584_DS1.pdf
• File Type:
  [PDF - 2.17 MB ]