Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium

Details

• Alternative Title:
  Nano Lett
• Personal Author:
  Williams, Ryan M. ; Shah, Janki ; Ng, Brandon D. ; Minton, Denise R. ; Gudas, Lorraine J. ; Park, Christopher Y. ; Heller, Daniel A.
• Description:
  We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology.
• Subjects:
  Animals Epithelium Female Kidney Tubules, Proximal Materials Testing Mice Mice, Nude Nanocapsules Organ Specificity Particle Size Polyethylene Glycols Polyglactin 910 Tissue Distribution

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• Keywords:
  Cancer Controlled Release Nanomedicine Nanotechnology Targeted Drug Delivery
• Source:
  Nano Lett. 15(4):2358-2364
• Pubmed ID:
  25811353
• Pubmed Central ID:
  PMC4518714
• Document Type:
  Journal Article
• Funding:
  DP2 HD075698/HD/NICHD NIH HHSUnited States/ ; T32 CA062948/CA/NCI NIH HHSUnited States/ ; 2 P30 CA008748-48/CA/NCI NIH HHSUnited States/ ; DP2-HD075698/DP/NCCDPHP CDC HHSUnited States/ ; T32CA062948/CA/NCI NIH HHSUnited States/ ; 1 S10 OD016207-01/OD/NIH HHSUnited States/ ; P30 CA008748/CA/NCI NIH HHSUnited States/ ; S10 OD016207/OD/NIH HHSUnited States/
• Volume:
  15
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6788b383bc1550ced486c7623809fe3dddfdb0542e117605552aa19accb60307
• Download URL:
  https://stacks.cdc.gov/view/cdc/32542/cdc_32542_DS1.pdf
• File Type:
  [PDF - 1.57 MB ]