Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Monroe, M. C. ; Morzunov, S. P. ; Johnson, A. M. ; Bowen, M. D. ; Artsob, H. ; Yates, T. ; Peters, C. J. ; Rollin, P. E. ; Ksiazek, T. G. ; Nichol, S. T.
• Description:
  The 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent-borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus). Hantavirus-infected rodents were identified in various regions of North America. An extensive nucleotide sequence database of an 139 bp fragment amplified from virus M genomic segments was generated. Phylogenetic analysis confirmed that SNV-like hantaviruses are widely distributed in Peromyscus species rodents throughout North America. Classic SNV is the major cause of HPS in North America, but other Peromyscine-borne hantaviruses, e.g., New York and Monongahela viruses, are also associated with HPS cases. Although genetically diverse, SNV-like viruses have slowly coevolved with their rodent hosts. We show that the genetic relationships of hantaviruses in the Americas are complex, most likely as a result of the rapid radiation and speciation of New World sigmodontine rodents and occasional virus-host switching events.
• Subjects:
  Animals Disease Reservoirs DNA, Viral Genetic Variation Hantavirus Hantavirus Pulmonary Syndrome Humans Mice Peromyscus Phylogeny Sequence Analysis, DNA

  More +
• Source:
  Emerg Infect Dis. 5(1):75-86.
• Document Type:
  Journal Article
• Place as Subject:
  North America
• Location:
  North America
• Volume:
  5
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:54f0ef2d09d11ef79de48097990a9d054b00e5b92c4c47fc26365369c5121405
• Download URL:
  https://stacks.cdc.gov/view/cdc/3252/cdc_3252_DS1.pdf
• File Type:
  [PDF - 1.96 MB ]