Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
McElroy, Kate L. ; Santiago, Gilberto A. ; Lennon, Niall J. ; Birren, Bruce W. ; Henn, Matthew R. ; ... More +
McElroy, Kate L. ; Santiago, Gilberto A. ; Lennon, Niall J. ; Birren, Bruce W. ; Henn, Matthew R. ; Muñoz-Jordán, Jorge L. Less -
Description:
To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994-1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution.
Subjects:
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Dengue Dengue Virus Disease Outbreaks Evolution, Molecular Genetic Variation Humans Incidence Phylogeny Research
Source:
Emerg Infect Dis. 17(1):64-71.
Document Type:
Journal Article
Place as Subject:
Puerto Rico
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:ac9dc1257e7ebfce402277f661440b200d6be06006f3338d968f6d6dfc15f29c
Download URL:
https://stacks.cdc.gov/view/cdc/3245/cdc_3245_DS1.pdf
File Type:

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