Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  McElroy, Kate L. ; Santiago, Gilberto A. ; Lennon, Niall J. ; Birren, Bruce W. ; Henn, Matthew R. ; Muñoz-Jordán, Jorge L.
• Description:
  To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994-1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution.
• Subjects:
  Dengue Dengue Virus Disease Outbreaks Evolution, Molecular Genetic Variation Humans Incidence Phylogeny Research
• Source:
  Emerg Infect Dis. 17(1):64-71.
• Document Type:
  Journal Article
• Place as Subject:
  Puerto Rico
• Location:
  Caribbean
• Volume:
  17
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ac9dc1257e7ebfce402277f661440b200d6be06006f3338d968f6d6dfc15f29c
• Download URL:
  https://stacks.cdc.gov/view/cdc/3245/cdc_3245_DS1.pdf
• File Type:
  [PDF - 744.37 KB ]