Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Publisher's site:
http://dx.doi.org/10.1002/bdra.23378
Personal Author:
Tinker, Sarah C. ; Hamner, Heather C. ; Qi, Yan Ping ; Crider, Krista S.
Tinker, Sarah C. ; Hamner, Heather C. ; Qi, Yan Ping ; Crider, Krista S. Less -
Description:
Background

Red blood cell (RBC) folate concentrations are a potential biomarker of folate-sensitive neural tube defect (NTD) risk in the population. The purpose of this analysis was to describe women in the U.S. population with RBC folate concentrations below those associated with optimal NTD prevention.

Methods

We used data from the 2007 to 2012 National Health and Nutrition Examination Survey (NHANES) to assess the RBC folate status of U.S. women of childbearing age relative to risk categories for NTD risk based on RBC folate concentrations. We defined suboptimal RBC folate concentrations as those associated with a prevalence of _9 NTDs per 10,000 live births.

Results

Among nonpregnant women age 12 to 49 years, 22.8% (95% Confidence Interval: 21.1, 24.6) had suboptimal RBC folate concentrations. Women had greater odds of having a suboptimal RBC folate concentration if they did not use dietary supplements containing folic acid; had mandatorily fortified enriched cereal grain products as their only source of folic acid; were non-Hispanic black or Hispanic; or were current smokers.

Conclusion

Based on RBC folate concentrations, we would predict that the majority of U.S. women of reproductive age are not at increased risk for folate sensitive NTDs in the presence of mandatory folic acid fortification. Prevention policies and programs can be aimed at population subgroups identified as having higher predicted risk for folate-sensitive NTDs based on RBC folate concentrations.


Subjects:
[+]
Adolescent Adult Article Biomarkers Erythrocytes Female Folic Acid Fortification Humans Neural Tube Defects NHANES Nutrition Surveys Optimal RBC Folate Concentration Pregnancy Risk Assessment United States
Source:
Birth Defects Res A Clin Mol Teratol. 103(6):517-526
Pubmed ID:
25884850
Pubmed Central ID:
PMC4515959
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a7e5fffb7ca80546ca7cfc6ecd999ee615c727072b9bd621d3fc988764452ec6
Download URL:
https://stacks.cdc.gov/view/cdc/32447/cdc_32447_DS1.pdf
File Type:

Supporting Files

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  	nihms703643f1.gif	gif
  	nihms703643f1.jpg	jpeg
  	nihms703643f2.gif	gif
  	nihms703643f2.jpg	jpeg

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