Details:

Alternative Title:
Expert Rev Pharmacoecon Outcomes Res
Personal Author:
Grosse, Scott D; Chaugule, Shraddha S; Hay, Joel W;
Grosse, Scott D; Chaugule, Shraddha S; Hay, Joel W; Less -
Description:
Estimates of preference-weighted health outcomes or health state utilities are needed to assess improvements in health in terms of quality-adjusted life-years. Gains in quality-adjusted life-years are used to assess the cost-effectiveness of prophylactic use of clotting factor compared with on-demand treatment among people with hemophilia, a congenital bleeding disorder. Published estimates of health utilities for people with hemophilia vary, contributing to uncertainty in the estimates of cost-effectiveness of prophylaxis. Challenges in estimating utility weights for the purpose of evaluating hemophilia treatment include selection bias in observational data, difficulty in adjusting for predictors of health-related quality of life and lack of preference-based data comparing adults with lifetime or primary prophylaxis versus no prophylaxis living within the same country and healthcare system.
Subject:
[+]
Adult
Article
Blood Coagulation Factors
Cost-Benefit Analysis
Delivery Of Health Care
Health Utilities
Hemophilia
Hemophilia A
Humans
Prophylaxis
Quality-adjusted Life-years
Quality-Adjusted Life Years
Quality Of Life
Selection Bias
Quality Of Life

Source:
Expert Rev Pharmacoecon Outcomes Res. 2015; 15(2):267-283;
Pubmed ID:
25585817
Pubmed Central ID:
PMC4513931
Document Type:
Journal Article;
Funding:
CC999999/Intramural CDC HHS/United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:348c7a97eed1c47cbd1be87c3aa4fe60ceabfe6323a0049f294f9008c7f46997
File Type:

Supporting Files

• nihms709091.nxml

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