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Estimates of utility weights in hemophilia: implications for cost-utility analysis of clotting factor prophylaxis
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Jan 14 2015
Source: Expert Rev Pharmacoecon Outcomes Res. 2015; 15(2):267-283
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Alternative Title:Expert Rev Pharmacoecon Outcomes Res
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Description:Estimates of preference-weighted health outcomes or health state utilities are needed to assess improvements in health in terms of quality-adjusted life-years. Gains in quality-adjusted life-years are used to assess the cost-effectiveness of prophylactic use of clotting factor compared with on-demand treatment among people with hemophilia, a congenital bleeding disorder. Published estimates of health utilities for people with hemophilia vary, contributing to uncertainty in the estimates of cost-effectiveness of prophylaxis. Challenges in estimating utility weights for the purpose of evaluating hemophilia treatment include selection bias in observational data, difficulty in adjusting for predictors of health-related quality of life and lack of preference-based data comparing adults with lifetime or primary prophylaxis versus no prophylaxis living within the same country and healthcare system.
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Pubmed ID:25585817
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Pubmed Central ID:PMC4513931
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