Estimates of utility weights in hemophilia: implications for cost-utility analysis of clotting factor prophylaxis

Grosse, Scott D; Chaugule, Shraddha S; Hay, Joel W

doi:10.1586/14737167.2015.1001372

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Estimates of utility weights in hemophilia: implications for cost-utility analysis of clotting factor prophylaxis

Published Date:

Jan 14 2015

Publisher's site:

http://dx.doi.org/10.1586/14737167.2015.1001372 New Site Icon

Source:

Expert Rev Pharmacoecon Outcomes Res. 2015; 15(2):267-283.

[PDF - 288.49 KB]

Details:

Personal Authors:

Grosse, Scott D ; Chaugule, Shraddha S ; Hay, Joel W ;

Keywords:

[+]

Pubmed ID:

25585817

Pubmed Central ID:

PMC4513931

Description:

Estimates of preference-weighted health outcomes or health state utilities are needed to assess improvements in health in terms of quality-adjusted life-years. Gains in quality-adjusted life-years are used to assess the cost-effectiveness of prophylactic use of clotting factor compared with on-demand treatment among people with hemophilia, a congenital bleeding disorder. Published estimates of health utilities for people with hemophilia vary, contributing to uncertainty in the estimates of cost-effectiveness of prophylaxis. Challenges in estimating utility weights for the purpose of evaluating hemophilia treatment include selection bias in observational data, difficulty in adjusting for predictors of health-related quality of life and lack of preference-based data comparing adults with lifetime or primary prophylaxis versus no prophylaxis living within the same country and healthcare system.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Supporting Files:

nihms709091.nxml

application/octet-stream

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