Estimates of utility weights in hemophilia: implications for cost-utility analysis of clotting factor prophylaxis

Details

• Alternative Title:
  Expert Rev Pharmacoecon Outcomes Res
• Personal Author:
  Grosse, Scott D ; Chaugule, Shraddha S ; Hay, Joel W
• Description:
  Estimates of preference-weighted health outcomes or health state utilities are needed to assess improvements in health in terms of quality-adjusted life-years. Gains in quality-adjusted life-years are used to assess the cost-effectiveness of prophylactic use of clotting factor compared with on-demand treatment among people with hemophilia, a congenital bleeding disorder. Published estimates of health utilities for people with hemophilia vary, contributing to uncertainty in the estimates of cost-effectiveness of prophylaxis. Challenges in estimating utility weights for the purpose of evaluating hemophilia treatment include selection bias in observational data, difficulty in adjusting for predictors of health-related quality of life and lack of preference-based data comparing adults with lifetime or primary prophylaxis versus no prophylaxis living within the same country and healthcare system.
• Subjects:
  Adult Article Blood Coagulation Factors Cost-Benefit Analysis Delivery Of Health Care Health Utilities Hemophilia Hemophilia A Humans Prophylaxis Quality-adjusted Life-years Quality-Adjusted Life Years Quality Of Life Selection Bias

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• Source:
  Expert Rev Pharmacoecon Outcomes Res. 2015; 15(2):267-283
• Pubmed ID:
  25585817
• Pubmed Central ID:
  PMC4513931
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  15
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:348c7a97eed1c47cbd1be87c3aa4fe60ceabfe6323a0049f294f9008c7f46997
• Download URL:
  https://stacks.cdc.gov/view/cdc/32419/cdc_32419_DS1.pdf
• File Type:
  [PDF - 288.49 KB ]