Elevated Transferrin Saturation, Health-Related Quality of Life and Telomere Length

Details

• Alternative Title:
  Biometals
• Personal Author:
  Mainous, Arch G. ; Wright, Robert U. ; Hulihan, Mary M. ; Twal, Waleed O. ; McLaren, Christine E. ; Diaz, Vanessa A. ; McLaren, Gordon D. ; Argraves, W. Scott ; Grant, Althea M.
• Description:
  We sought to examine the relationship between elevated transferrin saturation (TS) and measures of health status (telomere length and patient-reported health-related quality of life) to assess whether elevated TS is associated with negative patient outcomes beyond increased risk for morbidity and mortality, using a cross-sectional analysis of the Hemochromatosis and Iron Overload Screening Study supplemented with assays for leukocyte telomere length in adults ≥25 years old (n = 669). Among individuals with elevated TS (≥45 % for women and ≥50 % for men), who also had a usual source of care, only 5.2 % reported ever being told by a doctor that they had an elevated iron condition. In a fully adjusted general linear regression model controlling for demographic characteristics as well as health conditions associated with iron overload, elevated TS versus non-elevated TS was associated with worse general health status (60.4 vs. 63.8, P < 0.05), mental health status (76.5 vs. 82.2, P < 0.0001) and shorter telomere length (241.4 vs. 261.3, P < 0.05). Increased surveillance of elevated TS may be in order as elevated TS is associated with decreased health status and very few patients with elevated TS are aware of their condition.
• Subjects:
  Adult Article Female Functional Status Health Status Humans Iron Male Middle Aged Quality Of Life Real-Time Polymerase Chain Reaction Telomere Telomere Length Transferrin

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• Source:
  Biometals. 27(1):135-141.
• Pubmed ID:
  24337410
• Pubmed Central ID:
  PMC4034347
• Document Type:
  Journal Article
• Funding:
  AVU3/Intramural CDC HHS/United States ; F06 TW002117/TW/FIC NIH HHS/United States ; P20 GM103499/GM/NIGMS NIH HHS/United States ; P20 RR016434/RR/NCRR NIH HHS/United States ; P20 RR016434/RR/NCRR NIH HHS/United States ; P20 RR016461/RR/NCRR NIH HHS/United States ; P20RR16461/RR/NCRR NIH HHS/United States ; P30 CA062203/CA/NCI NIH HHS/United States
• Volume:
  27
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eba419f107e9cb010957fc0f05d5d669c804f32491d50c2b9c2b72ad16be916a
• Download URL:
  https://stacks.cdc.gov/view/cdc/32312/cdc_32312_DS1.pdf
• File Type:
  [PDF - 46.41 KB ]