Methicillin-Resistant Staphylococcus aureus Carriage and Risk Factors for Skin Infections, Southwestern Alaska, USA

Stevens, A Michal; Hennessy, Thomas; Baggett, Henry C; Bruden, Dana; Parks, Debbie; Klejka, Joseph

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Methicillin-Resistant Staphylococcus aureus Carriage and Risk Factors for Skin Infections, Southwestern Alaska, USA

Supporting Files Public Domain

May 2010
By Stevens, A Michal ; Hennessy, Thomas ; Baggett, Henry C ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Stevens, A Michal ; Hennessy, Thomas ; Baggett, Henry C ; Bruden, Dana ; Parks, Debbie ; Klejka, Joseph
Description:

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are common in southwestern Alaska Outbreak strains have been shown to carry the genes for Panton-Valentine leucocidin (PVL) To determine if carriage of PVL-positive CA-MRSA increased the risk for subsequent soft tissue infection, we conducted a retrospective cohort study by reviewing the medical records of 316 persons for 36 years after their participation in a MRSA nasal colonization survey Demographic, nasal carriage, and antimicrobial drug use data were analyzed for association with skin infection risk Skin infections were more likely to develop in MRSA carriers than in methicillin-susceptible S aureus carriers or noncarriers of S aureus during the first follow-up year, but not in subsequent years Repeated skin infections were more common among MRSA carriers In an area where PVL-containing MRSA is prevalent, skin infection risk was increased among MRSA nasal carriers compared with methicillin-susceptible S aureus carriers and noncarriers, but risk differential diminished over time
Subjects:

Adolescent Adult Age Aged Anti-Infective Agents Bacterial Toxins Carrier State Child Child, Preschool Cohort Studies Exotoxins Female Humans Infant Infant, Newborn Leukocidins Male Middle Aged Nasal Cavity Prevalence Research Retrospective Studies Risk Factors Staphylococcal Skin Infections Time Factors
Source:

Emerg Infect Dis 16(5):797-803
Document Type:

Journal Article
Place as Subject:

Alaska
Location:

Alaska
Volume:

16
Issue:

5
Collection(s):

CDC Public Access Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ecbc71efb9190faa4e48bb3cf3af5820210e311adcdb37748896c85ca12f435d
Download URL:

https://stacks.cdc.gov/view/cdc/3231/cdc_3231_DS1.pdf
File Type:

[PDF - 226.15 KB ]

File Language:

English

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