Methicillin-Resistant Staphylococcus aureus Carriage and Risk Factors for Skin Infections, Southwestern Alaska, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Stevens, A Michal ; Hennessy, Thomas ; Baggett, Henry C ; Bruden, Dana ; Parks, Debbie ; Klejka, Joseph
• Description:
  Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are common in southwestern Alaska Outbreak strains have been shown to carry the genes for Panton-Valentine leucocidin (PVL) To determine if carriage of PVL-positive CA-MRSA increased the risk for subsequent soft tissue infection, we conducted a retrospective cohort study by reviewing the medical records of 316 persons for 36 years after their participation in a MRSA nasal colonization survey Demographic, nasal carriage, and antimicrobial drug use data were analyzed for association with skin infection risk Skin infections were more likely to develop in MRSA carriers than in methicillin-susceptible S aureus carriers or noncarriers of S aureus during the first follow-up year, but not in subsequent years Repeated skin infections were more common among MRSA carriers In an area where PVL-containing MRSA is prevalent, skin infection risk was increased among MRSA nasal carriers compared with methicillin-susceptible S aureus carriers and noncarriers, but risk differential diminished over time
• Subjects:
  • Research
  • Adolescent
  • Adult
  • Aged
  • Age
  • Anti-Infective Agents
  • Bacterial Toxins
  • Carrier State
  • Child
  • Child, Preschool
  More +
• Source:
  Emerg Infect Dis 16(5):797-803
• Document Type:
  Journal Article
• Place as Subject:
  Alaska
• Location:
  Alaska
• Volume:
  16
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/3231/cdc_3231_DS1.pdf
• File Type:
  [PDF - 226.15 KB]
• Collection(s):
  Emerging Infectious Diseases ; CDC Public Access
• Main Document Checksum:
  urn:sha-512:32b959457bc5c07fd9fdfcb5a484c1feaf08c926681555c4ca9d6e726c9ad1a23aaac7e0de0bff5e3f220d0fb119cbe2913d9ee71450fe04680ec0fe6153cf6f