Details:

Alternative Title:
Environ Sci Technol
Publisher's site:
http://dx.doi.org/10.1021/es501811k
Personal Author:
Kato, Kayoko ; Wong, Lee-Yang ; Chen, Aimin ; Dunbar, Carmen ; Webster, Glenys ; ... More +
Kato, Kayoko ; Wong, Lee-Yang ; Chen, Aimin ; Dunbar, Carmen ; Webster, Glenys ; M. ; Lanphear, Bruce P. ; Calafat, Antonia M. ; Less -
Description:
Data on predictors of gestational exposure to poly- and perfluoroalkyl substances (PFASs) in the United States are limited. To fill in this gap, in a multiethnic cohort of Ohio pregnant women recruited in 2003-2006, we measured perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and six additional PFASs in maternal serum at ∼16 weeks gestation (N = 182) and delivery (N = 78), and in umbilical cord serum (N = 202). We used linear regression to examine associations between maternal serum PFASs concentrations and demographic, perinatal, and lifestyle factors. PFASs concentrations in maternal sera and in their infants' cord sera were highly correlated (Spearman rank correlation coefficients = 0.73-0.95). In 71 maternal-infant dyads, unadjusted geometric mean (GM) concentrations (95% confidence interval) (in μg/L) in maternal serum at delivery of PFOS [8.50 (7.01-9.58)] and PFOA [3.43 (3.01-3.90)] were significantly lower than at 16 weeks gestation [11.57 (9.90-13.53], 4.91 (4.32-5.59), respectively], but higher than in infants' cord serum [3.32 (2.84-3.89), 2.85 (2.51-3.24), respectively] (P < 0.001). Women who were parous, with a history of previous breastfeeding, black, or in the lowest income category had significantly lower PFOS and PFOA GM concentrations than other women. These data suggest transplacental transfer of PFASs during pregnancy and nursing for the first time in a U.S. birth cohort.
Subject:
[+]
Adult
Alkanesulfonic Acids
Caprylates
Cohort Studies
Environmental Exposure
Environmental Pollutants
Female
Fetal Blood
Fluorocarbons
Gestational Age
Humans
Infant, Newborn
Life Style
Linear Models
Maternal Exposure
Pregnancy

Source:
Environ Sci Technol. 2014; 48(16):9600-9608.
Pubmed ID:
25026485
Pubmed Central ID:
PMC4140533
Document Type:
Journal Article ;
Funding:
P01 ES11261/ES/NIEHS NIH HHS/United States ; R01 ES014575/ES/NIEHS NIH HHS/United States ; R01 ES020349/ES/NIEHS NIH HHS/United States ;
P01 ES11261/ES/NIEHS NIH HHS/United States ; R01 ES014575/ES/NIEHS NIH HHS/United States ; R01 ES020349/ES/NIEHS NIH HHS/United States ; Less -
Place as Subject:
Ohio ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d6424f4bd65ba27c85443d2a4c61306ac424e88e3951910a460896dfa83b483f
File Type:

Supporting Files

• 	license.txt	txt
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  	es-2014-01811k_0001.jpg	jpeg
  	es-2014-01811k_0002.gif	gif
  	es-2014-01811k_0002.jpg	jpeg
  	es501811k.nxml	txt
  	es501811k_si_001.pdf	pdf

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