Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Moodie, Claire E. ; Thompson, Herbert A. ; Meltzer, Martin I. ; Swerdlow, David L.
Moodie, Claire E. ; Thompson, Herbert A. ; Meltzer, Martin I. ; Swerdlow, David L. Less -
Description:
Coxiella burnetii is a category B bioterrorism agent. We numerically evaluated the risks and benefits from postexposure prophylaxis (PEP) after an intentional release of C. burnetii to the general population, pregnant women, and other high-risk populations. For each group, we constructed a decision tree to estimate illness and deaths averted by use of PEP/100,000 population. We calculated the threshold points at which the number of PEP-related adverse events was equal to the cases averted. PEP was defined as doxycycline (100 mg 2x/day for 5 days), except for pregnant women, where we assumed a PEP of trimethoprim-sulfamethoxazole (160 mg/800 mg 2x/day) for the duration of the pregnancy. PEP would begin 8-12 days postexposure. On the basis of upper-bound probability estimates of PEP-related adverse events for doxycycline, we concluded that the risk for Q fever illness outweighs the risk for antimicrobial drug-related adverse events when the probability of C. burnetii exposure is >or=7% (pregnant women using trimethoprim-sulfamethoxazole = 16%).
Subject:
[+]
Adult
Anti-Bacterial Agents
Bioterrorism
Child
Coxiella Burnetii
Coxiella Burnetti
Decision Trees
Doxycycline
Female
Heart Diseases
Heart Valve Diseases
Humans
Immunocompromised Host
Infant, Newborn
Male
Models, Biological
Pregnancy
Pregnancy Complications, Infectious
Pregnant Women
Prophylaxis
Q Fever
Research
Risk-benefit Assessment
Risk Assessment
Risk Factors
Trimethoprim, Sulfamethoxazole Drug Combination

Source:
Emerg Infect Dis. 14(10):1558-1566
Pubmed ID:
18826819
Pubmed Central ID:
PMC2609859
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:f25491e9d6b6b1a9e4fddd2c8372fd6a7fb13cb621b981e9a7c2248a3ef5e6ed
File Type:

Supporting Files

• 	08-0576_appT1-s1.pdf	pdf
  	08-0576_appT2-s2.pdf	pdf
  	08-0576_appT3-s3.pdf	pdf
  	08-0576_appT4-s4.pdf	pdf
  	08-0576_finalR.nxml	xml
  	08-0576_Techapp-s5.pdf	pdf
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