TLX: A Master Regulator for Neural Stem Cell Maintenance and Neurogenesis

Details

• Alternative Title:
  Biochim Biophys Acta
• Personal Author:
  Islam, Mohammed M. ; Zhang, Chun-Li
• Description:
  The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is specifically localized to the neurogenic regions of the forebrain and retina throughout development and adulthood. TLX regulates the expression of genes involved in multiple pathways, such as the cell cycle, DNA replication, and cell adhesion. These roles are primarily performed through the transcriptional repression or activation of downstream target genes. Emerging evidence suggests that the misregulation of TLX might play a role in the onset and progression of human neurological disorders making this factor an ideal therapeutic target. Here, we review the current understanding of TLX function, expression, regulation, and activity significant to NSC maintenance, adult neurogenesis, and brain plasticity. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
• Subjects:
  Adult Animals Article Cell Differentiation Humans Neural Stem Cell Neural Stem Cells Neurogenesis Neuronal Plasticity NR2E1 Nuclear Receptor Receptors, Cytoplasmic And Nuclear TLX

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• Source:
  Biochim Biophys Acta. 2014; 1849(2):210-216.
• Pubmed ID:
  24930777
• Pubmed Central ID:
  PMC4265312
• Document Type:
  Journal Article
• Funding:
  DP2 OD006484/OD/NIH HHS/United States ; R01 NS070981/NS/NINDS NIH HHS/United States ; 1DP20D006484/DP/NCCDPHP CDC HHS/United States ; R01NS070981/NS/NINDS NIH HHS/United States
• Volume:
  1849
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1e43721014f22430c03f4d60a0d896309de0ea2e6392bf50ba27aea5f4be9fd0
• Download URL:
  https://stacks.cdc.gov/view/cdc/32008/cdc_32008_DS1.pdf
• File Type:
  [PDF - 631.24 KB ]