Details:

Alternative Title:
PLoS One
Personal Author:
Cohen, Adam L. ; McMorrow, Meredith ; Walaza, Sibongile ; Cohen, Cheryl ; Tempia, Stefano ; ... More +
Cohen, Adam L. ; McMorrow, Meredith ; Walaza, Sibongile ; Cohen, Cheryl ; Tempia, Stefano ; Alexander-Scott, Marissa ; Widdowson, Marc-Alain Less -
Description:
Infectious diseases and underlying medical conditions common to Africa may affect influenza frequency and severity. We conducted a systematic review of published studies on influenza and the following co-infections or co-morbidities that are prevalent in Africa: dengue, malaria, measles, meningococcus, Pneumocystis jirovecii pneumonia (PCP), hemoglobinopathies, and malnutrition. Articles were identified except for influenza and PCP. Very few studies were from Africa. Sickle cell disease, dengue, and measles co-infection were found to increase the severity of influenza disease, though this is based on few studies of dengue and measles and the measles study was of low quality. The frequency of influenza was increased among patients with sickle cell disease. Influenza infection increased the frequency of meningococcal disease. Studies on malaria and malnutrition found mixed results. Age-adjusted morbidity and mortality from influenza may be more common in Africa because infections and diseases common in the region lead to more severe outcomes and increase the influenza burden. However, gaps exist in our knowledge about these interactions.
Subject:
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Anemia, Sickle Cell
Coinfection
Comorbidity
Dengue
Hemoglobinopathies
Humans
Influenza, Human
Malaria
Malnutrition
Measles
Severity Of Illness Index

Source:
PLoS One. 10(6)
Pubmed ID:
26068416
Pubmed Central ID:
PMC4466242
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:be036d05919c5b8da71898e8002f71283c327c8abd09af534a1db6feec69f3a8
File Type:

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