Details:

Alternative Title:
Am J Med Genet A
Publisher's site:
http://dx.doi.org/10.1002/ajmg.a.36272
Personal Author:
Zhu, Jin Liang ; Obel, Carsten ; Hasle, Henrik ; Rasmussen, Sonja A. ; Li, Jiong ; ... More +
Zhu, Jin Liang ; Obel, Carsten ; Hasle, Henrik ; Rasmussen, Sonja A. ; Li, Jiong ; Olsen, Jørn Less -
Description:
Today, most persons with Down syndrome (DS) survive into middle age, but information on their social conditions as adults is limited. We addressed this knowledge gap using data from national registers in Denmark. We identified a national cohort of 1,998 persons with DS who were born between 1968 and 2007 (1,852 with standard trisomy 21, 80 with Robertsonian translocations and 66 with mosaicism) using the Danish Cytogenetic Register. We followed this cohort from 1980 to 2007. Information on social conditions (education, employment, source of income, marital status, etc.) was obtained by linkages to national registers, including the Integrated Database for Longitudinal Labor Market Research. For those aged 18 and older, more than 80% of persons with DS attended 10 years of primary school, with about 2% completing secondary or post-secondary education. About 4% obtained a full-time job, whereas the remaining mainly received public support from the government. Only a few (1-2%) of persons with DS were married or had a child. No significant differences in these social conditions were seen between males and females. More persons with mosaic DS attended secondary or post-secondary education, had a full-time job, were married, or had a child (18%, 28%, 15%, and 7%, respectively), compared with persons with standard DS (1%, 2%, 1%, and 1%, respectively). These data may provide families with better insight into social conditions and society with a better understanding of the social support needed for persons with DS.
Subject:
[+]
Adolescent
Adult
Article
Child
Child, Preschool
Cohort Studies
Denmark
Down Syndrome
Female
Humans
Infant
Infant, Newborn
Karyotype
Male
Marital Status
Mosaic Trisomy 21
Offspring
Registries
Social Conditions
Socioeconomic Factors
Young Adult
Down Syndrome
Social Conditions

Source:
Am J Med Genet A. 2013; 0(1):36-41.
Pubmed ID:
24273114
Pubmed Central ID:
PMC4490827
Document Type:
Journal Article
Funding:
5 U10 DD000230-06/DD/NCBDD CDC HHS/United States ; SKR9/Intramural CDC HHS/United States
5 U10 DD000230-06/DD/NCBDD CDC HHS/United States ; SKR9/Intramural CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:cce5f5e3237b3c70b32fba52014d457b4239d7add2a9cd26d66f46e83424d989
File Type:

Supporting Files

• nihms702423.nxml

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