Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cama, Vitaliano A. ; Bern, Caryn ; Roberts, Jacqueline ; Cabrera, Lilia ; Sterling, Charles R. ; Ortega, Ynes ; Gilman, Robert H. ; Xiao, Lihua
• Description:
  To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.
• Subjects:
  Animals Child, Preschool Clinical Presentations Cohort Studies Cryptosporidiosis Cryptosporidium Cryptosporidium Parvum Diarrhea Feces Female Genotype Humans Infant Longitudinal Studies Male Molecular Epidemiology Pediatric Peru Research Risk Factors Subtype Virulence

  More +
• Source:
  Emerg Infect Dis. 14(10):1567-1574
• Pubmed ID:
  18826821
• Pubmed Central ID:
  PMC2609889
• Document Type:
  Journal Article
• Funding:
  U01-AI35894/AI/NIAID NIH HHS/United States ; U01 AI035894/AI/NIAID NIH HHS/United States ; P01 AI051976/AI/NIAID NIH HHS/United States ; R21 AI059661/AI/NIAID NIH HHS/United States ; 5R21 AI059661/AI/NIAID NIH HHS/United States ; 5P01AI051976/AI/NIAID NIH HHS/United States
• Volume:
  14
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:085aac7d283db75bc3d083ab913f9673022aafbb486265f6fc9d950b373d37f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/3187/cdc_3187_DS1.pdf
• File Type:
  [PDF - 138.50 KB ]