Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru

Cama, Vitaliano A.; Bern, Caryn; Roberts, Jacqueline; Cabrera, Lilia; Sterling, Charles R.; Ortega, Ynes; Gilman, Robert H.; Xiao, Lihua

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Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru

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Oct 2008
By Cama, Vitaliano A. ; Bern, Caryn ; Roberts, Jacqueline

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English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Cama, Vitaliano A. ; Bern, Caryn ; Roberts, Jacqueline ; Cabrera, Lilia ; Sterling, Charles R. ; Ortega, Ynes ; Gilman, Robert H. ; Xiao, Lihua
Description:

To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.
Subjects:
Source:

Emerg Infect Dis. 14(10):1567-1574
Pubmed ID:

18826821
Pubmed Central ID:

PMC2609889
Document Type:

Journal Article
Funding:

U01-AI35894/AI/NIAID NIH HHS/United States ; U01 AI035894/AI/NIAID NIH HHS/United States ; P01 AI051976/AI/NIAID NIH HHS/United States ; R21 AI059661/AI/NIAID NIH HHS/United States ; 5R21 AI059661/AI/NIAID NIH HHS/United States ; 5P01AI051976/AI/NIAID NIH HHS/United States
Volume:

14
Issue:

10
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https://stacks.cdc.gov/view/cdc/3187/cdc_3187_DS1.pdf
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[PDF - 138.50 KB]
Collection(s):

Emerging Infectious Diseases
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urn:sha-512:3dd00fb7afdb0c442192dab33b59899e19c792aa064dc8d01f807bfdf67596670a89d1c090fc57564aaad6d6a702c848ba87197347e1559b4f23f6ae663694b1

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