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Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
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Jul 2015
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Source: Emerg Infect Dis. 21(7):1237-1239
[PDF-805.30 KB]
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Alternative Title:Emerg Infect Dis
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Description:Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
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Pubmed ID:26079933
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Pubmed Central ID:PMC4480400
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Volume:21
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Issue:7
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