Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013

Hawkes, Michael; Conroy, Andrea L.; Opoka, Robert O.; Namasopo, Sophie; Zhong, Kathleen; Liles, W. Conrad; John, Chandy C.; Kain, Kevin C.

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Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013

Jul 2015
By Hawkes, Michael ; Conroy, Andrea L. ; Opoka, Robert O. ; ...
Source: Emerg Infect Dis. 21(7):1237-1239

[PDF-805.30 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Hawkes, Michael ; Conroy, Andrea L. ; Opoka, Robert O. ; Namasopo, Sophie ; Zhong, Kathleen ; ... More +

Hawkes, Michael ; Conroy, Andrea L. ; Opoka, Robert O. ; Namasopo, Sophie ; Zhong, Kathleen ; Liles, W. Conrad ; John, Chandy C. ; Kain, Kevin C. Less -
Description:

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
Subjects:

[+]

Antimalarials Artemisinins Child Child, Preschool Dispatch Drug Resistance Female Genes, Protozoan Humans Infant Malaria, Falciparum Male Polymorphism, Single Nucleotide Sequence Analysis, DNA
Source:

Emerg Infect Dis. 21(7):1237-1239
Pubmed ID:

26079933
Pubmed Central ID:

PMC4480400
Document Type:

Journal Article
Funding:

13721/Canadian Institutes of Health Research/Canada ; MOP-244701/Canadian Institutes of Health Research/Canada

13721/Canadian Institutes of Health Research/Canada ; MOP-244701/Canadian Institutes of Health Research/Canada Less -
Place as Subject:

Uganda
Location:

Africa
Volume:

21
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:aa14bc14aefa663022c61dc3c80cc83e7443169fdea712c7b4447e8a1b77a498
Download URL:

https://stacks.cdc.gov/view/cdc/31842/cdc_31842_DS1.pdf
File Type:

15-0213.nxml

xml

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