Transdermal Diagnosis of Malaria Using Vapor Nanobubbles

Lukianova-Hleb, Ekaterina; Bezek, Sarah; Szigeti, Reka; Khodarev, Alexander; Kelley, Thomas; Hurrell, Andrew; Berba, Michail; Kumar, Nirbhay; D’Alessandro, Umberto; Lapotko, Dmitri

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Transdermal Diagnosis of Malaria Using Vapor Nanobubbles

Published Date:

Jul 2015

Source:

Emerg Infect Dis. 21(7):1122-1127

Language:

English

[PDF-1.31 MB]

Details:

Personal Authors:

Lukianova-Hleb, Ekaterina ; Bezek, Sarah ; Szigeti, Reka ; Khodarev, Alexander ; Kelley, Thomas ; ... More ▼

Keywords:

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Pubmed ID:

26079141

Pubmed Central ID:

PMC4480396

Description:

A fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninvasive diagnosis of Plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. This method uses transdermal optical excitation and acoustic detection of vapor nanobubbles around intraparasite hemozoin. The same device also identified individual malaria parasite-infected Anopheles mosquitoes in a few seconds and can be realized as a low-cost universal tool for clinical and field diagnoses.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Funding:

AI47089/AI/NIAID NIH HHS/United States
R21 AI101427/AI/NIAID NIH HHS/United States
MC_UP_A900_1119/Medical Research Council/United Kingdom
R01 AI047089/AI/NIAID NIH HHS/United States
AI101427/AI/NIAID NIH HHS/United States

Main Document Checksum:

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Supporting Files:

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