Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lukianova-Hleb, Ekaterina ; Bezek, Sarah ; Szigeti, Reka ; Khodarev, Alexander ; Kelley, Thomas ; ... More +
Lukianova-Hleb, Ekaterina ; Bezek, Sarah ; Szigeti, Reka ; Khodarev, Alexander ; Kelley, Thomas ; Hurrell, Andrew ; Berba, Michail ; Kumar, Nirbhay ; D’Alessandro, Umberto ; Lapotko, Dmitri Less -
Description:
A fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninvasive diagnosis of Plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. This method uses transdermal optical excitation and acoustic detection of vapor nanobubbles around intraparasite hemozoin. The same device also identified individual malaria parasite-infected Anopheles mosquitoes in a few seconds and can be realized as a low-cost universal tool for clinical and field diagnoses.
Subjects:
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Animals Anopheles Anopheles Spp. Bloodless Diagnosis Female Hemozoin Humans Laser Malaria Nanobubble Nanotechnology Noninvasive Parasites Plasmodium Falciparum Research Skin Steam Transdermal Diagnosis Of Malaria Using Vapor Nanobubbles Vector-borne Infections
Source:
Emerg Infect Dis. 21(7):1122-1127
Pubmed ID:
26079141
Pubmed Central ID:
PMC4480396
Document Type:
Journal Article
Funding:
AI47089/AI/NIAID NIH HHS/United States ; R21 AI101427/AI/NIAID NIH HHS/United States ; MC_UP_A900_1119/Medical Research Council/United Kingdom ; R01 AI047089/AI/NIAID NIH HHS/United States ; AI101427/AI/NIAID NIH HHS/United States
AI47089/AI/NIAID NIH HHS/United States ; R21 AI101427/AI/NIAID NIH HHS/United States ; MC_UP_A900_1119/Medical Research Council/United Kingdom ; R01 AI047089/AI/NIAID NIH HHS/United States ; AI101427/AI/NIAID NIH HHS/United States Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:47444bfa3aca2f2756834d261fe1e7e9ce08853e609bcb6a4b3d025afa0e27c0
Download URL:
https://stacks.cdc.gov/view/cdc/31838/cdc_31838_DS1.pdf
File Type:

Supporting Files

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