Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1401.070822
Personal Author:
Bruce, Michael G. ; Deeks, Shelley L. ; Zulz, Tammy ; Navarro, Christine ; Palacios, Carolina ; ... More +
Bruce, Michael G. ; Deeks, Shelley L. ; Zulz, Tammy ; Navarro, Christine ; Palacios, Carolina ; Case, Cheryl ; Hemsley, Colleen ; Hennessy, Tom ; Corriveau, Andre ; Larke, Bryce ; Sobel, Isaac ; Lovgren, Marguerite ; DeByle, Carolynn ; Tsang, Raymond ; Parkinson, Alan J. Less -
Corporate Authors:
International Circumpolar Surveillance Hia Working Group
Description:
Before the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, rates of invasive H. influenzae disease among indigenous people of the North American Arctic were among the highest in the world. Routine vaccination reduced rates to low levels; however, serotype replacement with non-type b strains may result in a reemergence of invasive disease in children. We reviewed population-based data on invasive H. influenzae in Alaska and northern Canada from 2000-2005; 138 cases were reported. Among 88 typeable isolates, 42 (48%) were H. influenzae type a (Hia); 35 (83%) occurred in indigenous peoples. Among Hia patients, median age was 1.1 years; 62% were male; 1 adult died. Common clinical manifestations included meningitis, pneumonia, and septic arthritis. Overall annual incidence was 0.9 cases per 100,000 population. Incidence among indigenous children <2 years of age in Alaska and northern Canada was 21 and 102, respectively. Serotype a is now the most common H. influenzae serotype in the North American Arctic; the highest rates are among indigenous children.
Subject:
[+]
Adolescent
Adult
Aged
Age Factors
Alaska Natives
Child
Child, Preschool
Female
Haemophilus Infections
Humans
Incidence
Infant
Inuit
Male
Middle Aged
Population Surveillance
Serotyping

Source:
Emerg Infect Dis. 14(1):48-55.
Document Type:
Journal Article
Place as Subject:
Alaska ; Arctic Regions ; Canada
Alaska ; Arctic Regions ; Canada Less -
Collection(s):
Emerging Infectious Diseases
Arctic Investigations Program
Main Document Checksum:
[+]
urn:sha256:16b61f1b947b728018de97ef45892352f98b76f1afff334c5e7eda35fa0d418a
File Type:

Supporting Files

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