Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ladhani, Shamez N. ; Collins, Sarah ; Vickers, Anna ; Litt, David J. ; Crawford, Carina ; ... More +
Ladhani, Shamez N. ; Collins, Sarah ; Vickers, Anna ; Litt, David J. ; Crawford, Carina ; Ramsay, Mary E. ; Slack, Mary P.E. Less -
Description:
Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 days of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.
Subjects:
[+]
Adolescent Adult Aged Age Factors Child Child, Preschool Haemophilus Infections Humans Incidence Infant Infant, Newborn Middle Aged Multilocus Sequence Typing Serotyping Young Adult
Source:
Emerg Infect Dis. 18(5):725-732.
Document Type:
Journal Article
Place as Subject:
England ; Wales
England ; Wales Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:798f8b9bc42177856ad029c9d1ec325a5cd8229565c8e357f0a20488a9d9142f
Download URL:
https://stacks.cdc.gov/view/cdc/23921/cdc_23921_DS1.pdf
File Type:

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