Invasive Haemophilus influenzae Serotype e and f Disease, England and Wales

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ladhani, Shamez N. ; Collins, Sarah ; Vickers, Anna ; Litt, David J. ; Crawford, Carina ; Ramsay, Mary E. ; Slack, Mary P.E.
• Description:
  Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 days of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.
• Subjects:
  Adolescent Adult Aged Age Factors Child Child, Preschool Haemophilus Infections Humans Incidence Infant Infant, Newborn Middle Aged Multilocus Sequence Typing Serotyping Young Adult

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• Source:
  Emerg Infect Dis. 18(5):725-732.
• Document Type:
  Journal Article
• Place as Subject:
  England ; Wales
• Volume:
  18
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:798f8b9bc42177856ad029c9d1ec325a5cd8229565c8e357f0a20488a9d9142f
• Download URL:
  https://stacks.cdc.gov/view/cdc/23921/cdc_23921_DS1.pdf
• File Type:
  [PDF - 300.02 KB ]