Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1805.111738
Personal Author:
Ladhani, Shamez N. ; Collins, Sarah ; Vickers, Anna ; Litt, David J. ; Crawford, Carina ; ... More +
Ladhani, Shamez N. ; Collins, Sarah ; Vickers, Anna ; Litt, David J. ; Crawford, Carina ; Ramsay, Mary E. ; Slack, Mary P.E. Less -
Description:
Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 days of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.
Subject:
[+]
Adolescent
Adult
Aged
Age Factors
Bacteria
Child
Child, Preschool
CME
Collins S
Crawford D
England
England And Wales. Emerg Infect Dis [serial On The Internet]. 2012 May [date Cited]. Http://dx.doi.org/10.3201/eid1805.111738
Epidemiology
Et Al. Invasive Haemophilus Influenzae Serotype E And F Disease
Haemophilus Infections
Haemophilus Influenzae
Hie
Hif
Humans
Incidence
Infant
Infant, Newborn
Litt DJ
Middle Aged
MLST
Multilocus Sequence Typing
Outcome
Ramsay ME
Research
Respiratory Tract Diseases
Risk Factors
Serotypes
Serotyping
Suggested Citation For This Article: Ladhani SN
Vickers A
Wales
Young Adult

Source:
Emerg Infect Dis. 18(5):725-732.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:798f8b9bc42177856ad029c9d1ec325a5cd8229565c8e357f0a20488a9d9142f
File Type:

Supporting Files

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