Details:

Alternative Title:
Thromb Res
Personal Author:
Yusuf, Hussain R. ; Hooper, W. Craig ; Grosse, Scott D. ; Parker, Christopher S. ; Boulet, Sheree L. ; ... More +
Yusuf, Hussain R. ; Hooper, W. Craig ; Grosse, Scott D. ; Parker, Christopher S. ; Boulet, Sheree L. ; Ortel, Thomas L. Less -
Description:
Objective

This study assessed the risk of venous thromboembolism (VTE) among privately insured adults in the U.S. with one or more of the following autoimmune diseases: autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE).

Materials and Methods

Using the Truven Health MarketScan® Databases, patients 18–64 years of age with a diagnosis of AIHA, ITP, RA, or SLE in 2007 and a sex and age-group matched comparison group of enrollees were followed up through 2010 to identify VTE events. Survival curve and Cox proportional hazards analyses were conducted to assess differences between groups.

Results

Among patients with AIHA, ITP, RA, or SLE, or >1 of these diseases, the risk of at least one VTE event was 19.74, 7.72, 4.90, 9.89, and 13.35 per 1,000 person-years, respectively; among the comparison group, the risk was 1.91 per 1,000 person-years. The adjusted hazard ratios (aHRs) for VTE among patients with AIHA, ITP, RA, or SLE, or >1 of these diseases (when compared with the comparison group) tended to decline over follow-up time; at 1 year, the aHRs were 6.30 (95% confidence interval [CI]: 4.44–8.94), 2.95 (95% CI: 2.18–4.00), 2.13 (95% CI: 1.89–2.40), 4.68 (95% CI: 4.10–5.33), and 5.11 (95% CI: 4.26–6.14), respectively.

Conclusion

Having AIHA, ITP, RA, or SLE, or >1 of these diseases was associated with an increased likelihood of a VTE event. More research is necessary to develop better understanding of VTE occurrence among people with autoimmune diseases.


Subjects:
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Adolescent Adult Algorithms Anemia, Hemolytic, Autoimmune Arthritis, Rheumatoid Autoimmune Diseases Cohort Studies Female Humans Incidence Insurance, Health Lupus Erythematosus, Systemic Male Middle Aged Proportional Hazards Models Purpura, Thrombocytopenic, Idiopathic Retrospective Studies Treatment Outcome Venous Thromboembolism Young Adult
Source:
Thromb Res. 135(1):50-57
Pubmed ID:
25456001
Pubmed Central ID:
PMC4480419
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1880f2ac8aa9d503a95ff8fdffa9fac5b9bea0e70dfe8c8c9d98f4262e15d743
Download URL:
https://stacks.cdc.gov/view/cdc/31758/cdc_31758_DS1.pdf
File Type:

Supporting Files

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