Risk of venous thromboembolism occurrence among adults with selected autoimmune diseases: A study among a U.S. cohort of commercial insurance enrollees☆

Details

• Alternative Title:
  Thromb Res
• Personal Author:
  Yusuf, Hussain R. ; Hooper, W. Craig ; Grosse, Scott D. ; Parker, Christopher S. ; Boulet, Sheree L. ; Ortel, Thomas L.
• Description:
  Objective ; This study assessed the risk of venous thromboembolism (VTE) among privately insured adults in the U.S. with one or more of the following autoimmune diseases: autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). ; Materials and Methods ; Using the Truven Health MarketScan® Databases, patients 18–64 years of age with a diagnosis of AIHA, ITP, RA, or SLE in 2007 and a sex and age-group matched comparison group of enrollees were followed up through 2010 to identify VTE events. Survival curve and Cox proportional hazards analyses were conducted to assess differences between groups. ; Results ; Among patients with AIHA, ITP, RA, or SLE, or >1 of these diseases, the risk of at least one VTE event was 19.74, 7.72, 4.90, 9.89, and 13.35 per 1,000 person-years, respectively; among the comparison group, the risk was 1.91 per 1,000 person-years. The adjusted hazard ratios (aHRs) for VTE among patients with AIHA, ITP, RA, or SLE, or >1 of these diseases (when compared with the comparison group) tended to decline over follow-up time; at 1 year, the aHRs were 6.30 (95% confidence interval CI: 4.44–8.94), 2.95 (95% CI: 2.18–4.00), 2.13 (95% CI: 1.89–2.40), 4.68 (95% CI: 4.10–5.33), and 5.11 (95% CI: 4.26–6.14), respectively. ; Conclusion ; Having AIHA, ITP, RA, or SLE, or >1 of these diseases was associated with an increased likelihood of a VTE event. More research is necessary to develop better understanding of VTE occurrence among people with autoimmune diseases.
• Subjects:
  • Adolescent
  • Adult
  • Algorithms
  • Anemia, Hemolytic, Autoimmune
  • Arthritis, Rheumatoid
  • Autoimmune Diseases
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  More +
• Keywords:
  • Autoimmune diseases
  • Autoimmune hemolytic anemia
  • Immune thrombocytopenic purpura
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Venous thromboembolism
• Source:
  Thromb Res. 135(1):50-57
• Pubmed ID:
  25456001
• Pubmed Central ID:
  PMC4480419
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  135
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/31758/cdc_31758_DS1.pdf
• File Type:
  [PDF - 1.03 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1880f2ac8aa9d503a95ff8fdffa9fac5b9bea0e70dfe8c8c9d98f4262e15d743