Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Reynolds, Mary G. ; Davidson, Whitni B. ; Curns, Aaron T. ; Conover, Craig S. ; Huhn, Gregory ; ... More +
Reynolds, Mary G. ; Davidson, Whitni B. ; Curns, Aaron T. ; Conover, Craig S. ; Huhn, Gregory ; Davis, Jeffrey P. ; Wegner, Mark ; Croft, Donita R. ; Newman, Alexandra ; Obiesie, Nkolika N. ; Hansen, Gail R. ; Hays, Patrick L. ; Pontones, Pamela ; Beard, Brad ; Teclaw, Robert ; Howell, James F. ; Braden, Zachary ; Holman, Robert C. ; Karem, Kevin L. ; Damon, Inger K. Less -
Description:
For the 2003 monkeypox virus (MPXV) outbreak in the United States, interhuman transmission was not documented and all case-patients were near or handled MPXV-infected prairie dogs. We initiated a case-control study to evaluate risk factors for animal-to-human MPXV transmission. Participants completed a questionnaire requesting exposure, clinical, and demographic information. Serum samples were obtained for analysis of immunoglobulin G (IgG) and IgM to orthopoxvirus. When data were adjusted for smallpox vaccination, case-patients were more likely than controls to have had daily exposure to a sick animal (odds ratio [OR] 4.0, 95% confidence interval [CI] 1.2-13.4), cleaned cages and bedding of a sick animal (OR 5.3, 95% CI 1.4-20.7), or touched a sick animal (OR 4.0, 95% CI 1.2-13.4). These findings demonstrate that human MPXV infection is associated with handling of MPXV-infected animals and suggest that exposure to excretions and secretions of infected animals can result in infection.
Subjects:
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Adolescent Adult Animals Case-Control Studies Humans Odds Ratio Research Risk Factors Sciuridae
Source:
Emerg Infect Dis. 13(9):1332-1339.
Document Type:
Journal Article
Place as Subject:
United States
Location:
North America
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:5e51793667ff14d1da2f4d1cf6ea95b1e6b7bcef6aacfb15787a4d6023a06f1b
Download URL:
https://stacks.cdc.gov/view/cdc/3174/cdc_3174_DS1.pdf
File Type:

Supporting Files

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