Spectrum of Infection and Risk Factors for Human Monkeypox, United States, 2003

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Reynolds, Mary G. ; Davidson, Whitni B. ; Curns, Aaron T. ; Conover, Craig S. ; Huhn, Gregory ; Davis, Jeffrey P. ; Wegner, Mark ; Croft, Donita R. ; Newman, Alexandra ; Obiesie, Nkolika N. ; Hansen, Gail R. ; Hays, Patrick L. ; Pontones, Pamela ; Beard, Brad ; Teclaw, Robert ; Howell, James F. ; Braden, Zachary ; Holman, Robert C. ; Karem, Kevin L. ; Damon, Inger K.
• Description:
  For the 2003 monkeypox virus (MPXV) outbreak in the United States, interhuman transmission was not documented and all case-patients were near or handled MPXV-infected prairie dogs. We initiated a case-control study to evaluate risk factors for animal-to-human MPXV transmission. Participants completed a questionnaire requesting exposure, clinical, and demographic information. Serum samples were obtained for analysis of immunoglobulin G (IgG) and IgM to orthopoxvirus. When data were adjusted for smallpox vaccination, case-patients were more likely than controls to have had daily exposure to a sick animal (odds ratio [OR] 4.0, 95% confidence interval [CI] 1.2-13.4), cleaned cages and bedding of a sick animal (OR 5.3, 95% CI 1.4-20.7), or touched a sick animal (OR 4.0, 95% CI 1.2-13.4). These findings demonstrate that human MPXV infection is associated with handling of MPXV-infected animals and suggest that exposure to excretions and secretions of infected animals can result in infection.
• Subjects:
  Adolescent Adult Animals Case-Control Studies Humans Odds Ratio Research Risk Factors Sciuridae
• Source:
  Emerg Infect Dis. 13(9):1332-1339.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  13
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5e51793667ff14d1da2f4d1cf6ea95b1e6b7bcef6aacfb15787a4d6023a06f1b
• Download URL:
  https://stacks.cdc.gov/view/cdc/3174/cdc_3174_DS1.pdf
• File Type:
  [PDF - 193.24 KB ]