Asbestosis and environmental causes of usual interstitial pneumonia

Details

• Alternative Title:
  Curr Opin Pulm Med
• Personal Author:
  Gulati, Mridu ; Redlich, Carrie A.
• Description:
  Purpose of review
  
  Recent epidemiologic investigations suggest that occupational and environmental exposures contribute to the overall burden of idiopathic pulmonary fibrosis (IPF). This article explores the epidemiologic and clinical challenges to establishing exposure associations, the current literature regarding exposure disease relationships and the diagnostic work-up of IPF and asbestosis patients.
  
  Recent findings
  
  IPF patients demonstrate a histopathologic pattern of usual interstitial pneumonia. In the absence of a known cause or association, a usual interstitial pneumonia pattern leads to an IPF diagnosis, which is a progressive and often terminal fibrotic lung disease. It has long been recognized that asbestos exposure can cause pathologic and radiographic changes indistinguishable from IPF. Several epidemiologic studies, primarily case control in design, have found that a number of other exposures that can increase risk of developing IPF include cigarette smoke, wood dust, metal dust, sand/silica and agricultural exposures. Lung mineralogic analyses have provided additional support to causal associations. Genetic variation may explain differences in disease susceptibility among the population.
  
  Summary
  
  An accumulating body of literature suggests that occupational and environmental exposure can contribute to the development of IPF. The impact of exposure on the pathogenesis and clinical course of disease requires further study.
  
  
• Subjects:
  Asbestos Asbestosis Environmental Exposure Humans Lung Diseases, Interstitial Occupational Diseases Risk Factors
• Source:
  Curr Opin Pulm Med. 2015; 21(2):193-200
• Pubmed ID:
  25621562
• Pubmed Central ID:
  PMC4472384
• Document Type:
  Journal Article
• Funding:
  K01 OH008644/OH/NIOSH CDC HHSUnited States/ ; R01 HL109233/HL/NHLBI NIH HHSUnited States/ ; U01 HL112702/HL/NHLBI NIH HHSUnited States/
• Volume:
  21
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:055148c4bcc44dfa87ef36909aa0bec60be75d235a68632a6deb4dc775f973f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/31681/cdc_31681_DS1.pdf
• File Type:
  [PDF - 990.38 KB ]